Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives

Szczegóły
Opis

Tytuł :: Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives
Autorzy :: Tijen Önkol
Akalin G
Mustafa Fethi Sahin
Murat Sukuroglu
Onurdağ Fk; Pokaż więcej
Temat :: General Biochemistry, Genetics and Molecular Biology
Nuclear magnetic resonance spectroscopy
Gram-negative bacteria
biology.organism_classification
biology
Antimicrobial
Biological activity
Chemistry
Antimycobacterial
medicine.drug_class
medicine
Gram-positive bacteria
Stereochemistry
Moiety
Bacteria
Antimicrobial Activity
Benzyliden-Acetohydrazide
Pyridazinone
Źródło :: Zeitschrift für Naturforschung C. 67:0257
Wydawca :: Walter de Gruyter GmbH, 2012.
Rok publikacji :: 2012
Opis pliku :: application/pdf
ISSN :: 0939-5075
0003-0805
DOI :: 10.5560/znc.2012.67c0257
Dostępność :: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8786673b20da260d13de59d859f362dd
Prawa :: OPEN
Numer akcesji :: edsair.doi.dedup.....8786673b20da260d13de59d859f362dd

WOS: 000308054900004
PubMed ID: 22888530
New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, H-1 NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N'-(4-tert-butylbenzyliden)acetohydrazide and 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N'-(4-chlorobenzyliden) acetohydrazide exhibited activity against both Gram-positive and Gram-negative bacteria. Most of the compounds were active against E. coli ATCC 35218. The preliminary results of this study revealed that some target compounds exhibited promising antimicrobial activities.
Gazi University Research Fund [02/2009-05]
This study was supported by Gazi University Research Fund (project no. 02/2009-05).

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