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Tytuł pozycji:

CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

Tytuł :
CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo
Autorzy :
Oldenhove, Guillaume
de Heusch, Magali
Urbain-Vansanten, Georgette
Urbain, Jacques
Maliszewski, Charlie
Leo, Oberdan
Moser, Muriel
Pokaż więcej
Temat :
regulation
Toll-like receptors
primary response
inflammation
chemical and pharmacologic phenomena
hemic and immune systems
T helper cell type 1/type 2 balance
Article
Źródło :
The Journal of Experimental Medicine
Wydawca :
The Rockefeller University Press, 2003.
Rok publikacji :
2003
Oryginalny identyfikator :
pmc: PMC2194073
pmid: 12874259
Język :
English
ISSN :
1540-9538
0022-1007
DOI :
10.1084/jem.20030654
Recent evidence suggests that in addition to their well known stimulatory properties, dendritic cells (DCs) may play a major role in peripheral tolerance. It is still unclear whether a distinct subtype or activation status of DC exists that promotes the differentiation of suppressor rather than effector T cells from naive precursors. In this work, we tested whether the naturally occurring CD4+ CD25+ regulatory T cells (Treg) may control immune responses induced by DCs in vivo. We characterized the immune response induced by adoptive transfer of antigen-pulsed mature DCs into mice depleted or not of CD25+ cells. We found that the development of major histocompatibility complex class I and II–restricted interferon γ–producing cells was consistently enhanced in the absence of Treg. By contrast, T helper cell (Th)2 priming was down-regulated in the same conditions. This regulation was independent of interleukin 10 production by DCs. Of note, splenic DCs incubated in vitro with Toll-like receptor ligands (lipopolysaccharide or CpG) activated immune responses that remained sensitive to Treg function. Our data further show that mature DCs induced higher cytotoxic activity in CD25-depleted recipients as compared with untreated hosts. We conclude that Treg naturally exert a negative feedback mechanism on Th1-type responses induced by mature DCs in vivo.

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