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Tytuł pozycji:

What is microglia neurotoxicity (Not)?

Tytuł :
What is microglia neurotoxicity (Not)?
Autorzy :
Biber, Knut
Owens, Trevor
Boddeke, Erik
Pokaż więcej
Temat :
Activation states
Microglia evolution
Neuroinflammation
Neuronal loss
Aging/metabolism
Animals
Microglia/chemistry
Neurons/metabolism
Humans
Nervous System Diseases/metabolism
Brain/metabolism
Źródło :
Biber, K, Owens, T & Boddeke, E 2014, ' What is microglia neurotoxicity (Not)? ', Glia, vol. 62, no. 6, pp. 841-854 . https://doi.org/10.1002/glia.22654
Rok publikacji :
2014
Kolekcja :
University_of_Southern_Denmark_Research_Output
Język :
English
ISSN :
0894-1491
DOI :
10.1002/glia.22654
Numer akcesji :
edsair.od......3062..1894f05fd8d414a15b072902cc202f05
Microglia most likely appeared early in evolution as they are not only present in vertebrates, but are also found in nervous systems of various nonvertebrate organisms. Mammalian microglia are derived from a specific embryonic, self-renewable myeloid cell population that is throughout lifetime not replaced by peripheral myeloid cells. These phylogenic and ontogenic features suggest that microglia serve vital functions. Yet, microglia often are described as neurotoxic cells, that actively kill (healthy) neurons. Since it is from an evolutionary point of view difficult to understand why an important and vulnerable organ like the brain should host numerous potential killers, we here review the concept of microglia neurotoxicity. On one hand it is discussed that most of our understanding about how microglia kill neurons is based on in vitro experiments or correlative staining studies that suffer from the difficulty to discriminate microglia and peripheral myeloid cells in the diseased brain. On the other hand it is described that a more functional approach by mutating, inactivating or deleting microglia is seldom associated with a beneficial outcome in an acute injury situation, suggesting that microglia are normally important protective elements in the brain. This might change in chronic disease or the aged brain, where; however, it remains to be established whether microglia simply lose their protective capacities or whether microglia become truly neurotoxic cells. GLIA 2014.

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