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Tytuł pozycji:

Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation:an individual patient data meta-analysis of randomised trials

Tytuł :
Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation:an individual patient data meta-analysis of randomised trials
Autorzy :
Taylor, Rod S
Walker, Sarah
Smart, Neil A
Piepoli, Massimo F
Warren, Fiona C
Ciani, Oriana
O'Connor, Christopher
Whellan, David
Keteyian, Steven J
Coats, Andrew
Davos, Constantinos H
Dalal, Hasnain M
Dracup, Kathleen
Evangelista, Lorraine
Jolly, Kate
Myers, Jonathan
McKelvie, Robert S
Nilsson, Birgitta B
Passino, Claudio
Witham, Miles D
Yeh, Gloria Y
Zwisler, Ann-Dorthe O
Pokaż więcej
Temat :
Cardiac rehabilitation
Exercise training
Meta-analysis
Systematic review
Cardiac Rehabilitation/methods
Global Health
Humans
Randomized Controlled Trials as Topic/methods
Hospitalization
Heart Failure/mortality
Survival Rate/trends
Exercise
Quality of Life
Exercise Therapy/methods
Źródło :
ExTraMATCH II Collaboration 2018, ' Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation : an individual patient data meta-analysis of randomised trials ', European Journal of Heart Failure, vol. 20, no. 12, pp. 1735-1743 . https://doi.org/10.1002/ejhf.1311
Rok publikacji :
2018
Kolekcja :
University_of_Southern_Denmark_Research_Output
University_of_Southern_Denmark_Research_Output_enriched
Opis pliku :
application/pdf
Język :
English
ISSN :
1388-9842
DOI :
10.1002/ejhf.1311
Numer akcesji :
edsair.od......3062..2483ebe31647f6cb1f269e6fc0a2f11d
AIMS: To undertake an individual patient data (IPD) meta-analysis to assess the impact of exercise-based cardiac rehabilitation (ExCR) in patients with heart failure (HF) on mortality and hospitalisation, and differential effects of ExCR according to patient characteristics: age, sex, ethnicity, New York Heart Association functional class, ischaemic aetiology, ejection fraction, and exercise capacity.METHODS AND RESULTS: Randomised trials of exercise training for at least 3 weeks compared with no exercise control with 6-month follow-up or longer, providing IPD time to event on mortality or hospitalisation (all-cause or HF-specific). IPD were combined into a single dataset. We used Cox proportional hazards models to investigate the effect of ExCR and the interactions between ExCR and participant characteristics. We used both two-stage random effects and one-stage fixed effect models. IPD were obtained from 18 trials including 3912 patients with HF with reduced ejection fraction. Compared to control, there was no statistically significant difference in pooled time to event estimates in favour of ExCR although confidence intervals (CIs) were wide [all-cause mortality: hazard ratio (HR) 0.83, 95% CI 0.67-1.04; HF-specific mortality: HR 0.84, 95% CI 0.49-1.46; all-cause hospitalisation: HR 0.90, 95% CI 0.76-1.06; and HF-specific hospitalisation: HR 0.98, 95% CI 0.72-1.35]. No strong evidence was found of differential intervention effects across patient characteristics.CONCLUSION: Exercise-based cardiac rehabilitation did not have a significant effect on the risk of mortality and hospitalisation in HF with reduced ejection fraction. However, uncertainty around effect estimates precludes drawing definitive conclusions.
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