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Tytuł pozycji:

Reproducibility and replicability of rodent phenotyping in preclinical studies

Tytuł :
Reproducibility and replicability of rodent phenotyping in preclinical studies
Autorzy :
Kafkafi, Neri
Agassi, Joseph
Chesler, Elissa J.
Crabbe, John C.
Crusio, Wim E.
Eilam, David
Gerlai, Robert
Golani, Ilan
Gomez-Marin, Alex
Heller, Ruth
Iraqi, Fuad
Jaljuli, Iman
Karp, Natasha A.
Morgan, Hugh
Nicholson, George
Pfaff, Donald W.
Richter, S. Helene
Stark, Philip B.
Stiedl, Oliver
Stodden, Victoria
Tarantino, Lisa M.
Tucci, Valter
Valdar, William
Williams, Robert W.
Würbel, Hanno
Benjamini, Yoav
Pokaż więcej
Wydawca :
Cold Spring Harbor Laboratory, 2016.
Rok publikacji :
2016
Język :
English
DOI :
10.1101/079350
Numer akcesji :
edsair.sharebioRxiv..db8fecfec008e6e74bb067b2f166d155
The scientific community is increasingly concerned with cases of published “discoveries” that are not replicated in further studies. The field of mouse behavioral phenotyping was one of the first to raise this concern, and to relate it to other complicated methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of the mouse as a model animal for human health and disease mechanisms. In January 2015, researchers from various disciplines including genetics, behavior genetics, neuroscience, ethology, statistics and bioinformatics gathered in Tel Aviv University to discuss these issues. The general consent presented here was that the issue is prevalent and of concern, and should be addressed at the statistical, methodological and policy levels, but is not so severe as to call into question the validity and the usefulness of model organisms as a whole. Well-organized community efforts, coupled with improved data and metadata sharing, were agreed by all to have a key role to play in identifying specific problems and promoting effective solutions. As replicability is related to validity and may also affect generalizability and translation of findings, the implications of the present discussion reach far beyond the issue of replicability of mouse phenotypes but may be highly relevant throughout biomedical research.

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