The proposed method for the determination of salbutamol is based on its reaction with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) in borate buffer of the pH = 7.4š0.1. In this reaction a yellow coloured species is produced, which can be detected spectrophotometrically at the wavelength of 392 nm. The absorbance-concentration plot is linear over the range 4-24 žg mL-1. The minimum detectability (S/N = 2) was 0.4 žg mL-1(1.67 × 10-6mol L-1) with correlation coefficient (n = 5) of 0.9998. The molar absorptivity was 8.11 × 104L mol-1cm-1. Various experimental conditions affecting the developmentand stability of the produced colour were carefully studied and optimised. The proposed method was successfully applied to the determination of salbutamol in its dosage forms. The percentage recoveries šSD (n = 4) were 99.66š0.37 and 100.20š1.08 for tablets containing 2.0 mg of salbutamol and syrup containing 40 mg of salbutamol per 100 mL, respectively. The results obtained were in good agreement with those obtained with the reference spectrophotometric method. A possible reaction pathway between the analyte and NBD-Cl is proposed.