Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization

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Opis

Tytuł:: Association of genetically predicted blood sucrose with coronary heart disease and its risk factors in Mendelian randomization
Autorzy:: Ting Zhang
Shiu Lun Au Yeung
C. Mary Schooling
Temat:: Medicine
Science
Źródło:: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Wydawca:: Nature Portfolio, 2020.
Rok publikacji:: 2020
Kolekcja:: LCC:Medicine
LCC:Science
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 2045-2322
Relacje:: https://doaj.org/toc/2045-2322
DOI:: 10.1038/s41598-020-78685-5
Dostęp URL:: https://doaj.org/article/020a3e8b5d2c424cb1398fde3c902bbc Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.020a3e8b5d2c424cb1398fde3c902bbc
: Czasopismo naukowe

Pełny tekst

Abstract We assessed the associations of genetically instrumented blood sucrose with risk of coronary heart disease (CHD) and its risk factors (i.e., type 2 diabetes, adiposity, blood pressure, lipids, and glycaemic traits), using two-sample Mendelian randomization. We used blood fructose as a validation exposure. Dental caries was a positive control outcome. We selected genetic variants strongly (P

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