Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

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Tytuł:: Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens
Autorzy:: Nicholas D. Walter
Sarah E. M. Born
Gregory T. Robertson
Matthew Reichlen
Christian Dide-Agossou
Victoria A. Ektnitphong
Karen Rossmassler
Michelle E. Ramey
Allison A. Bauman
Victor Ozols
Shelby C. Bearrows
Gary Schoolnik
Gregory Dolganov
Benjamin Garcia
Emmanuel Musisi
William Worodria
Laurence Huang
J. Lucian Davis
Nhung V. Nguyen
Hung V. Nguyen
Anh T. V. Nguyen
Ha Phan
Carol Wilusz
Brendan K. Podell
N’ Dira Sanoussi
Bouke C. de Jong
Corinne S. Merle
Dissou Affolabi
Helen McIlleron
Maria Garcia-Cremades
Ekaterina Maidji
Franceen Eshun-Wilson
Brandon Aguilar-Rodriguez
Dhuvarakesh Karthikeyan
Khisimuzi Mdluli
Cathy Bansbach
Anne J. Lenaerts
Radojka M. Savic
Payam Nahid
Joshua J. Vásquez
Martin I. Voskuil
Temat:: Science
Źródło:: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Wydawca:: Nature Portfolio, 2021.
Rok publikacji:: 2021
Kolekcja:: LCC:Science
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 2041-1723
Relacje:: https://doaj.org/toc/2041-1723
DOI:: 10.1038/s41467-021-22833-6
Dostęp URL:: https://doaj.org/article/e0c6c2c659ca434dbad834a1759cfbb7 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.0c6c2c659ca434dbad834a1759cfbb7
: Czasopismo naukowe

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It is unclear why different antibiotics vary in their ability to shorten treatment of tuberculosis. Here, the authors show that a measure based on ribosomal RNA synthesis in Mycobacterium tuberculosis correlates with treatment shortening in culture, in mice and in human studies.

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