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Tytuł pozycji:

Clinical features of Guillain–Barré syndrome patients with elevated serum creatine kinase levels

Tytuł:
Clinical features of Guillain–Barré syndrome patients with elevated serum creatine kinase levels
Autorzy:
Takafumi Hosokawa
Hideto Nakajima
Taiki Sawai
Yoshitsugu Nakamura
Eri Sano
Akihiro Tsukahara
Kiichi Unoda
Shimon Ishida
Sadaki Sakane
Fumiharu Kimura
Shigeki Arawaka
Temat:
Creatine kinase
Guillain-Barré syndrome
AIDP
AMAN
Reversible conduction failure
Neurology. Diseases of the nervous system
RC346-429
Źródło:
BMC Neurology, Vol 20, Iss 1, Pp 1-9 (2020)
Wydawca:
BMC, 2020.
Rok publikacji:
2020
Kolekcja:
LCC:Neurology. Diseases of the nervous system
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1471-2377
Relacje:
http://link.springer.com/article/10.1186/s12883-020-01796-z; https://doaj.org/toc/1471-2377
DOI:
10.1186/s12883-020-01796-z
Dostęp URL:
https://doaj.org/article/ca11d5073c8a41a8bc7229bb208e72c3  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.11d5073c8a41a8bc7229bb208e72c3
Czasopismo naukowe
Abstract Background It is not well defined whether Guillain–Barré syndrome (GBS) patients with elevated serum creatine kinase (CK) levels have characteristic clinical features and are related to the subgroups of GBS. Methods We retrospectively studied 51 consecutive patients with GBS, who visited our hospital, and compared clinical, laboratory and electrophysiological findings between patients with and without elevated CK levels. Results Of 51 patients, 14 patients (27%) showed an elevation of serum CK levels. When compared with patients with the normal CK levels, the ratios of male, antecedent infections, and anti-GM1 antibody positivity were significantly higher in patients with elevated CK levels. The ratios of hypoesthesia, cranial nerve involvement, and urinary retention were significantly less in patients with elevated CK levels. There were no significant differences in disability at peak between two groups. In the electrophysiological examination, sensory nerve abnormalities were not observed. Although some patients with elevated CK levels showed prolongation of distal motor latencies (DMLs) and increase of durations in the initial examination, development of the prolongation of DMLs and increase of durations was not observed in the follow-up examinations. The findings were consistent with acute motor axonal neuropathy (AMAN) with reversible conduction failure (RCF) but not acute inflammatory demyelinating polyneuropathy (AIDP). Conclusions The results suggest that the GBS patients with elevated CK levels represent not a group of AIDP but a group of AMAN with axonal degeneration or RCF even though the initial electrophysiological examination shows AIDP pattern.
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