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Tytuł:
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Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms
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Autorzy:
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Marcelo H. Petri, MD, PhD
Silke Thul, PhD
Teodora Andonova, MSc
Moritz Lindquist-Liljeqvist, MD
Hong Jin, MD, PhD
Nikolaos-Taxiarchis Skenteris, MSc
Hildur Arnardottir, PhD
Lars Maegdefessel, MD, PhD
Kenneth Caidahl, MD, PhD
Mauro Perretti, PhD
Joy Roy, MD, PhD
Magnus Bäck, MD, PhD
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Temat:
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Diseases of the circulatory (Cardiovascular) system
RC666-701
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Źródło:
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JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 719-727 (2018)
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Wydawca:
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Elsevier, 2018.
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Rok publikacji:
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2018
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Kolekcja:
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LCC:Diseases of the circulatory (Cardiovascular) system
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Typ dokumentu:
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article
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Opis pliku:
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electronic resource
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Język:
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English
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ISSN:
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2452-302X
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Relacje:
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http://www.sciencedirect.com/science/article/pii/S2452302X18302249; https://doaj.org/toc/2452-302X
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DOI:
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10.1016/j.jacbts.2018.08.005
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Dostęp URL:
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https://doaj.org/article/164a8f2077224d33babc47d27d6edaae  Link otwiera się w nowym oknie
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Numer akcesji:
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edsdoj.164a8f2077224d33babc47d27d6edaae
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Summary: An abdominal aortic aneurysm (AAA) is a progressive aortic dilation that may lead to rupture, which is usually lethal. This study identifies the state of failure in the resolution of inflammation by means of decreased expression of the pro-resolving receptor A lipoxin/formyl peptide receptor 2 (ALX/FPR2) in the adventitia of human AAA lesions. Mimicking this condition by genetic deletion of the murine ALX/FPR2 ortholog in hyperlipidemic mice exacerbated the aortic dilation induced by angiotensin II infusion, associated with decreased vascular collagen and increased inflammation. The authors also identified key roles of lipoxin formation through 12/15-lipoxygenase and neutrophil p38 mitogen-activated protein kinase. In conclusion, this study established pro-resolving signaling by means of the ALX/FPR2 receptor in aneurysms and vascular inflammation. Key Words: abdominal aortic aneurysms, cardiovascular disease, eicosanoids, inflammation, lipoxygenase