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Tytuł pozycji:

PHYTOCHEMICAL PROFILE AND GASTROPROTECTIVE ACTIVITY OF EUGENIA MATTOSII FRUITS

Tytuł:
PHYTOCHEMICAL PROFILE AND GASTROPROTECTIVE ACTIVITY OF EUGENIA MATTOSII FRUITS
Autorzy:
Luana dos SANTOS
Adriana CAMPOS
Valdir CECHINEL FILHO
Luciane Angela Nottar NESELLO
Temat:
Gastrointestinal diseases, therapy
Eugenia
Anti-ulcer agentes
pharmacology
Gastric mucosa, drug effects
Diseases of the digestive system. Gastroenterology
RC799-869
Źródło:
Arquivos de Gastroenterologia, Vol 55, Iss 2, Pp 138-141
Wydawca:
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE).
Kolekcja:
LCC:Diseases of the digestive system. Gastroenterology
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1678-4219
0004-2803
Relacje:
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018000200138&lng=en&tlng=en; https://doaj.org/toc/1678-4219
DOI:
10.1590/s0004-2803.201800000-24
Dostęp URL:
https://doaj.org/article/175621a9647d4cd7b633e1aa21bdbcb0  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.175621a9647d4cd7b633e1aa21bdbcb0
Czasopismo naukowe
ABSTRACT BACKGROUND: Extracts obtained from plants and fruits provide a relatively safe and practical alternative for the conventional medicine of gastrointestinal diseases. The specie Eugenia mattosii, popularly known in Brazil as “cerejinha”, belongs to Myrtaceae family. Species of this family present pharmacological properties, and can be used in the treatment of gastrointestinal disorders. OBJECTIVE: The aim of this study was to determine the phytochemical profile and evaluate the gastroprotective activity of Eugenia mattosii fruits. METHODS: Phytochemical analysis was carried out by thin layer chromatography and gastroprotective assays were performed using two experimental models: acute ulcer model induced by ethanol/HCl and acute ulcer model induced by non-steroidal anti-inflammatory drug (indomethacin). Total lesion area (mm2) and relative lesion area (%) were determined. RESULTS: The results of the phytochemical analysis indicated that the bark and pulp and seeds of E. mattosii present phenolic compounds, terpenes and/or steroids. In gastric ulcer model induced by ethanol was evidenced significant reduction of damaged areas for doses of 50 and 250 mg/ kg of seeds methanol extract, while in the indomethacin-induced ulcer model, all parts of the fruit presented defense capability of the gastric mucosa by reducing lesions at doses of 50, 125 and 250 mg/kg. CONCLUSION: The results demonstrate that the specie E. mattosii has bioactive compounds that provide gastroprotective activity, presenting possible therapeutic potential.

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