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Title of the item:

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Title :
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Authors :
Takayoshi Awakawa
Takuma Fujioka
Lihan Zhang
Shotaro Hoshino
Zhijuan Hu
Junko Hashimoto
Ikuko Kozone
Haruo Ikeda
Kazuo Shin-Ya
Wen Liu
Ikuro Abe
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Subject Terms :
Science
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Publisher :
Nature Publishing Group, 2018.
Publication Year :
2018
Collection :
LCC:Science
Document Type :
article
File Description :
electronic resource
Language :
English
ISSN :
2041-1723
Relation :
https://doaj.org/toc/2041-1723
DOI :
10.1038/s41467-018-05877-z
Access URL :
https://doaj.org/article/209bc4d1b5344a32b292f405caa6ac8b
Accession Number :
edsdoj.209bc4d1b5344a32b292f405caa6ac8b
Academic Journal
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones.

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