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Tytuł pozycji:

Epidemiology and Clinicopathological Profile of Renal Cell Carcinoma

Tytuł:
Epidemiology and Clinicopathological Profile of Renal Cell Carcinoma
Autorzy:
Likhiteswer Pallagani
Gautam Ram Choudhary
Himanshu Pandey
Vijay Kumar Sarma Madurri
mahendra singh tanwar
Prateek Gupta
Nikita Shrivastava
Gaurav Baid
Meenakshi Rao
Aasma Nalwa
Puneet Pareek
Sanjeev Misra
Temat:
Renal cell carcinoma, western India, Epidemiology, minimally invasive surgery
Diseases of the genitourinary system. Urology
RC870-923
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło:
Journal of Kidney Cancer and VHL, Vol 8, Iss 1 (2021)
Wydawca:
Codon Publications, 2021.
Rok publikacji:
2021
Kolekcja:
LCC:Diseases of the genitourinary system. Urology
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
2203-5826
Relacje:
https://jkcvhl.com/index.php/jkcvhl/article/view/154; https://doaj.org/toc/2203-5826
DOI:
10.15586/jkcvhl.v8i1.154
Dostęp URL:
https://doaj.org/article/29e34adb3b0542249dad833f134f3c0f  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.29e34adb3b0542249dad833f134f3c0f
Czasopismo naukowe
Renal cell carcinoma (RCC) accounts for 3% of all adult cancers and 85% of all kidney tumours. Incidence of RCC is lower in Asian region, particularly in India, probably due to lack of reporting. Most of the data about RCC are from Western countries; and data from India are scarce, especially regarding para-neoplastic syndromes. We sought to determine the epidemiology, clinicopathological profile and management of RCC in a tertiary care centre in Western India. This was a retrospective study that involved data analysis of records of RCC patients who presented to our institution from April 2016 to Feb-ruary 2020. Laboratory investigations, including tests for paraneoplastic syndrome (PNS), and relevant radiologic investigations were performed and treatment was offered according to the stage, patient factors and available modalities. A total 142 RCC patients were included in the study. The median age of presentation was 58 years. Most of the patients (67%) were symptom-atic, and 33% of the patients were asymptomatic, and the RCC was diagnosed incidentally. A large number of patients (56.3%) had PNS. The most common histopathologic type of RCC was clear cell carcinoma (68.8%), followed by papillary (20%) and chromophobe (8%) carcinoma. 40% of carcinomas with sarcomatoid differentiation were seen in patients under 50 years of age. Two cases of multicystic RCC were both seen in patients less than 50 years of age. 65.5% of the patients presented at Stage 1 and 2. Most surgeries (71.2%) were done in a minimally invasive manner. A significant number of patients were asymptomatic, in which RCC was detected incidentally. The age of presentation was earlier, yet the patients had a higher tumour stage. More than half of the patients had PNSs. Despite growing trend towards Western data, the significantly higher number of patients with PNSs and early age of presentation suggest inherent differences in tumour biology, possibly related to differences in genetic and environmental factors.

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