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Tytuł pozycji:

Prevention of mother-to-child transmission of hepatitis B virus in Burkina Faso: Screening, vaccination and evaluation of post-vaccination antibodies against hepatitis B surface antigen in newborns

Tytuł:
Prevention of mother-to-child transmission of hepatitis B virus in Burkina Faso: Screening, vaccination and evaluation of post-vaccination antibodies against hepatitis B surface antigen in newborns
Autorzy:
Edwige T. Yelemkoure
Albert T. Yonli
Carla Montesano
Abdoul Karim Ouattara
Birama Diarra
Théodora M. Zohoncon
Christelle W.M. Nadembega
Paul Ouedraogo
Charles Sombié
Serge Theophile Soubeiga
Issoufou Tao
Adama Gansane
Massimo Amicosante
Florencia Djigma
Dorcas Obiri-Yeboah
Virginio Pietra
Jacques Simpore
Vittorio Colizzi
Temat:
Viral Hepatitis B, HBsAg, Real- Time PCR, Vertical Transmission, Vaccination.
Public aspects of medicine
RA1-1270
Źródło:
Journal of Public Health in Africa, Vol 9, Iss 3 (2018)
Wydawca:
PAGEPress Publications, 2018.
Rok publikacji:
2018
Kolekcja:
LCC:Public aspects of medicine
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
2038-9922
2038-9930
Relacje:
https://www.publichealthinafrica.org/index.php/jphia/article/view/816; https://doaj.org/toc/2038-9922; https://doaj.org/toc/2038-9930
DOI:
10.4081/jphia.2018.816
Dostęp URL:
https://doaj.org/article/2c2e7ffbcdbf4726aae21f3b0a7d4365  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.2c2e7ffbcdbf4726aae21f3b0a7d4365
Czasopismo naukowe
The low rate of screening for hepatitis B virus (HBV) in pregnant women is a highrisk factor for its vertical transmission. The objectives of this study were: i) to screen pregnant women for HBV infection; ii) vaccinate all children from birth against HBV regardless their mother HBV status; and iii) evaluate after 7 months of birth the level of their AbHBs among babies who received HBV vaccine at birth. Serological markers of HBV (HBsAg, HBeAg, AbHBs, AbHBe, and AbHBc) were determined on venous blood samples from 237 pregnant women and their children using the Abon Biopharm Kit. One hundred and two (102) children received the three doses of the EUVAX B® vaccine respectively at birth, two months and four months of life. Seven months after delivery, venous blood samples were collected from mothers and their children. Antibodies against hepatitis B surface antigen (AbHBs) were measured in vaccinated children using the ELISA Kit AbHBs Quantitative EIA. DNA extraction was performed on samples from HBV-seropositive mothers and their children using the Ribo Virus (HBV Real-TM Qual) Kit and for Real Time PCR, the HBV Real-TM Qual Kit was used. Serological diagnosis in pregnant women revealed 22 (9.28%) hepatitis B surface antigen (HBsAg) positive samples of which 21 were positive for viral DNA by real-time PCR. Among the 22 HBsAg+ women, five (05) transmitted the virus to their children with a vertical transmission rate of 22.73%. A transmission rate of 23.81% (5/21) was found with the PCR method. Analysis of AbHBs levels revealed that 98.31% of the children had an average concentration of 218.07 ± 74.66 IU/L, which is well above the minimum threshold for protection (11 IU/L). This study has confirmed that vertical transmission of HBV is a reality in Burkina Faso and that vaccination at birth would significantly reduce this transmission.

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