Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Tytuł:: Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
Autorzy:: Zhu Liang
Andreas Damianou
Elena Di Daniel
Benedikt M. Kessler
Temat:: NLRP3 inflammasome
Post-translational modifications
Protein interaction
Signalling
Drug targets
Medicine
Cytology
QH573-671
Źródło:: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Wydawca:: BMC, 2021.
Rok publikacji:: 2021
Kolekcja:: LCC:Medicine
LCC:Cytology
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 1478-811X
Relacje:: https://doaj.org/toc/1478-811X
DOI:: 10.1186/s12964-020-00688-6
Dostęp URL:: https://doaj.org/article/2e71fa84571f402fb0574b920e429024 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.2e71fa84571f402fb0574b920e429024
: Czasopismo naukowe

Pełny tekst

Abstract Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM enzymes that modify NLRP3, ASC/PYCARD and caspase-1, leading to inflammasome regulation, activation and signal termination. Potential target therapeutic entry points for a number of inflammatory diseases focussed on PTM enzyme readers, writers and erasers, leading to the regulation of inflammasome function, are discussed. Video Abstract

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