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Tytuł pozycji:

Active Components of Commonly Prescribed Medicines Affect Influenza A Virus–Host Cell Interaction: A Pilot Study

Tytuł:
Active Components of Commonly Prescribed Medicines Affect Influenza A Virus–Host Cell Interaction: A Pilot Study
Autorzy:
Aleksandr Ianevski
Rouan Yao
Eva Zusinaite
Hilde Lysvand
Valentyn Oksenych
Tanel Tenson
Magnar Bjørås
Denis Kainov
Temat:
influenza virus
virus–host interaction
commonly prescribed drugs
drug adverse reaction
Microbiology
QR1-502
Źródło:
Viruses, Vol 13, Iss 8, p 1537 (2021)
Wydawca:
MDPI AG, 2021.
Rok publikacji:
2021
Kolekcja:
LCC:Microbiology
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1999-4915
Relacje:
https://www.mdpi.com/1999-4915/13/8/1537; https://doaj.org/toc/1999-4915
DOI:
10.3390/v13081537
Dostęp URL:
https://doaj.org/article/31aafb39201d413c9947156e2d02557b  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.31aafb39201d413c9947156e2d02557b
Czasopismo naukowe
Background: Every year, millions of people are hospitalized and thousands die from influenza A virus (FLUAV) infection. Most cases of hospitalizations and death occur among the elderly. Many of these elderly patients are reliant on medical treatment of underlying chronic diseases, such as arthritis, diabetes, and hypertension. We hypothesized that the commonly prescribed medicines for treatment of underlying chronic diseases can affect host responses to FLUAV infection and thus contribute to the morbidity and mortality associated with influenza. Therefore, the aim of this study was to examine whether commonly prescribed medicines could affect host responses to virus infection in vitro. Methods: We first identified 45 active compounds from a list of commonly prescribed medicines. Then, we constructed a drug–target interaction network and identified the potential implication of these interactions for FLUAV–host cell interplay. Finally, we tested the effect of 45 drugs on the viability, transcription, and metabolism of mock- and FLUAV-infected human retinal pigment epithelial (RPE) cells. Results: In silico drug–target interaction analysis revealed that drugs such as atorvastatin, candesartan, and hydroxocobalamin could target and modulate FLUAV–host cell interaction. In vitro experiments showed that at non-cytotoxic concentrations, these compounds affected the transcription and metabolism of FLUAV- and mock-infected cells. Conclusion: Many commonly prescribed drugs were found to modulate FLUAV–host cell interactions in silico and in vitro and could therefore affect their interplay in vivo, thus contributing to the morbidity and mortality of patients with influenza virus infections.
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