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Tytuł pozycji:

Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates

Tytuł:
Association of Procalcitonin to Albumin Ratio with the Presence and Severity of Sepsis in Neonates
Autorzy:
Li T
Li X
Liu X
Zhu Z
Zhang M
Xu Z
Wei Y
Feng Y
Qiao X
Yang J
Dong G
Temat:
procalcitonin to albumin ratio
neonatal sepsis
severe sepsis
predictor.
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Źródło:
Journal of Inflammation Research, Vol Volume 15, Pp 2313-2321 (2022)
Wydawca:
Dove Medical Press, 2022.
Rok publikacji:
2022
Kolekcja:
LCC:Pathology
LCC:Therapeutics. Pharmacology
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1178-7031
Relacje:
https://www.dovepress.com/association-of-procalcitonin-to-albumin-ratio-with-the-presence-and-se-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
Dostęp URL:
https://doaj.org/article/341f23b0ac1547f78da2779dc5534663  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.341f23b0ac1547f78da2779dc5534663
Czasopismo naukowe
Tiewei Li,1,* Xiaojuan Li,1,* Xinrui Liu,1 Zhiwei Zhu,1 Min Zhang,1 Zhe Xu,1 Yulei Wei,1 Yichuang Feng,1 Xiaoliang Qiao,2 Junmei Yang,1 Geng Dong1 1Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, People’s Republic of China; 2Center of Laboratory Medicine, Women & Infants Hospital of Zhengzhou, Zhengzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junmei Yang; Geng Dong, Email yangjunmei7683@163.com; donggeng90@126.comPurpose: Previous studies have demonstrated that procalcitonin and albumin have a close correlation with sepsis. However, the role of procalcitonin (PCT) to albumin (ALB) ratio (PAR) in sepsis was still unclear, especially in neonates. Thus, this study aimed to investigate the association between PAR and neonatal sepsis.Patients and Methods: A total of 1,196 neonates with suspected sepsis were included in this study. Neonates were divided into control group and sepsis group, according to whether they were diagnosed with sepsis. Neonates with sepsis were further divided into mild sepsis and severe sepsis group according to the severity of sepsis. PAR was calculated as serum PCT (ng/mL)/ALB (mg/mL). All statistical analyses were performed using the statistical package SPSS 24.0, as appropriate.Results: Compared with the control group, neonates with sepsis had a higher PAR. PAR also showed a significant gradual increase in the control, mild sepsis, and severe sepsis groups (P< 0.001). Correlation analysis showed that there was a strong positive correlation between PAR and hsCRP, neonatal sequential organ failure assessment score (nSOFA), and prolonged length of hospital stay (P< 0.001). On multiple logistic regression, higher PAR was independently associated with the presence and severity of neonatal sepsis. According to the receiver operating characteristic curve analysis, a PAR ≥ 0.065 had 64% sensitivity and 72% specificity in predicting the presence of neonatal sepsis (area under curve (AUC)=0.72, 95% CI=0.69– 0.75, P< 0.001) and a PAR≥ 0.070 had 69% sensitivity and 63% specificity in predicting the presence of severe sepsis (AUC=0.71, 95% CI=0.68– 0.74, P< 0.001).Conclusion: PAR is significantly higher in neonates with sepsis and correlated with the severity of the disease. Increased PAR is an independent predictor useful for identifying the presence and severity of neonatal sepsis.Keywords: procalcitonin-to-albumin ratio, neonatal sepsis, severe sepsis, predictor

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