An analytical review of modern sources of scientific literature on the pathogenesis of chronic endometritis and its effect on reproductive loss has been performed. The analysis of 32 foreign and 11 domestic sources. The role of the association of complicated forms of the chronic inflammatory process in the tissues of the reproductive tract with the presence of polymorphic variants of hemostasis system genes is described. The prospect of studying the relationship of the gene mutation of the factor XIII hemostasis system with the formation of chronic endometritis, endometrial fibrosis, and habitual miscarriage is estimated. The analysis shows that knowledge of the details of the pathogenetic mechanism will allow us to build a personalized rehabilitation strategy for the patient after an episode of miscarriage, pregravid preparation and accompanying subsequent pregnancy.