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Tytuł pozycji:

Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: An ecological study

Tytuł :
Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: An ecological study
Autorzy :
Tseng Ching-Yu
Huang Yi-Chia
Su Shih-Yung
Huang Jing-Yang
Lai Cheng-Hsiu
Lung Chia-Chi
Ho Chien-Chang
Liaw Yung-Po
Pokaż więcej
Temat :
Lung cancer
Squamous cell carcinoma
Adenocarcinoma
Sulfur dioxide
Age-standardized incidence rate
Public aspects of medicine
RA1-1270
Źródło :
BMC Public Health, Vol 12, Iss 1, p 4 (2012)
Wydawca :
BMC, 2012.
Rok publikacji :
2012
Kolekcja :
LCC:Public aspects of medicine
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1471-2458
Relacje :
http://www.biomedcentral.com/1471-2458/12/4; https://doaj.org/toc/1471-2458
DOI :
10.1186/1471-2458-12-4
Dostęp URL :
https://doaj.org/article/4261b20a82624728ba157922ca2434a1
Numer akcesji :
edsdoj.4261b20a82624728ba157922ca2434a1
Czasopismo naukowe
Abstract Background Many studies have examined the association between air pollutants (including sulfur dioxide [SO2], carbon monoxide [CO], nitrogen dioxide [NO2], nitric oxide [NO], ozone [O3], and particulate matter < 10 μm [PM10]) and lung cancer. However, data from previous studies on pathological cell types were limited, especially for SO2 exposure. We aimed to explore the association between SO2 exposure from outdoor air pollutants and female lung cancer incidence by cell type specificity. Methods We conducted an ecological study and calculated annual average concentration of 6 air pollutants (SO2, CO, NO2, NO, O3, and PM10) using data from Taiwan Environmental Protection Administration air quality monitoring stations. The Poisson regression models were used to evaluate the association between SO2 and age-standardized incidence rate of female lung cancer by two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]). In order to understand whether there is a dose-response relationship between SO2 and two major pathological types, we analyzed 4 levels of exposure based on quartiles of concentration of SO2. Results The Poisson regression results showed that with the first quartile of SO2 concentration as the baseline, the relative risks for AC/SCC type cancer among females were 1.20 (95% confidence interval [CI], 1.04-1.37)/1.39 (95% CI, 0.96-2.01) for the second, 1.22 (95% CI, 1.04-1.43)/1.58 (95% CI, 1.06-2.37) for the third, and 1.27 (95% CI, 1.06-1.52)/1.80 (95% CI, 1.15-2.84) for the fourth quartile of SO2 concentration. The tests for trend were statistically significant for both AC and SCC at P = 0.0272 and 0.0145, respectively. Conclusion The current study suggests that SO2 exposure as an air pollutant may increase female lung cancer incidence and the associations with female lung cancer is much stronger for SCC than for AC. The findings of this study warrant further investigation on the role of SO2 in the etiology of SCC.

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