Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

FMNL3 is Overexpressed in Tumor Tissues and Predicts an Immuno-Hot Phenotype in Pancreatic Cancer

Tytuł:
FMNL3 is Overexpressed in Tumor Tissues and Predicts an Immuno-Hot Phenotype in Pancreatic Cancer
Autorzy:
Zhang Q
Nie H
Pan J
Xu H
Zhan Q
Temat:
fmnl3
paad
tumor microenvironment
bioinformatics analysis
formin
Medicine (General)
R5-920
Źródło:
International Journal of General Medicine, Vol Volume 15, Pp 8285-8298 (2022)
Wydawca:
Dove Medical Press, 2022.
Rok publikacji:
2022
Kolekcja:
LCC:Medicine (General)
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1178-7074
Relacje:
https://www.dovepress.com/fmnl3-is-overexpressed-in-tumor-tissues-and-predicts-an-immuno-hot-phe-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074
Dostęp URL:
https://doaj.org/article/c45a9de12d2149d4a132ea7c906969c6  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.45a9de12d2149d4a132ea7c906969c6
Czasopismo naukowe
Qinglin Zhang,* He Nie,* Jiadong Pan, Haoran Xu, Qiang Zhan Department of Gastroenterology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214023, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qinglin Zhang; Qiang Zhan, Email zhang517068@126.com; ryzhanqiang@163.comBackground: FMNL3 (Formin-like protein 3) is involved in the tumorigenesis of multiple cancers. The critical role of FMNL3 in malignancies has been preliminarily explored, but its immunological correlation is not clear.Methods: A pan-cancer analysis was performed to investigate the expressions, prognostic values, and immunological roles of FMNL3 across cancer types in The Cancer Genome Atlas (TCGA) database. Next, the correlations between FMNL3 and immunological features in the tumor microenvironment (TME) of pancreatic cancer (PAAD) were assessed. Besides, the role of FMNL3 in predicting the clinical characteristics and the responses to various therapies in PAAD was evaluated as well. Besides, the correlations between FMNL3 and the emerging immune-related biomarkers were also evaluated.Results: The pan-cancer analysis uncovered inconsistent expression status and prognostic values in several cancers. Besides, FMNL3 exhibited positive correlations with a majority of immunomodulators and tumor-infiltrating immune cells (TIICs) in several cancer types, including PAAD. In addition, FMNL3 was associated with an inflamed phenotype in the TME and predicted significantly higher responses to multiple anti-cancer therapies. In addition, FMNL3 was notably correlated with immune-related microbiota and N6-methyladenosine (m6A) genes.Conclusion: In summary, FMNL3 predicts an immuno-hot phenotype, which could be a promising indicator for identifying high immunogenicity in PAAD.Keywords: FMNL3, PAAD, tumor microenvironment, bioinformatics analysis, formin

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies