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Tytuł pozycji:

The Role of Epigenetics in Congenital Heart Disease

Tytuł:
The Role of Epigenetics in Congenital Heart Disease
Autorzy:
Tingsen Benson Lim
Sik Yin Roger Foo
Ching Kit Chen
Temat:
cardiogenesis
cardiac development
epigenetics
transcriptional regulation
congenital heart disease
Genetics
QH426-470
Źródło:
Genes, Vol 12, Iss 3, p 390 (2021)
Wydawca:
MDPI AG, 2021.
Rok publikacji:
2021
Kolekcja:
LCC:Genetics
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
2073-4425
Relacje:
https://www.mdpi.com/2073-4425/12/3/390; https://doaj.org/toc/2073-4425
DOI:
10.3390/genes12030390
Dostęp URL:
https://doaj.org/article/4801c076892d42cfaf70fa8655e345e5  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.4801c076892d42cfaf70fa8655e345e5
Czasopismo naukowe
Congenital heart disease (CHD) is the most common birth defect among newborns worldwide and contributes to significant infant morbidity and mortality. Owing to major advances in medical and surgical management, as well as improved prenatal diagnosis, the outcomes for these children with CHD have improved tremendously so much so that there are now more adults living with CHD than children. Advances in genomic technologies have discovered the genetic causes of a significant fraction of CHD, while at the same time pointing to remarkable complexity in CHD genetics. For this reason, the complex process of cardiogenesis, which is governed by multiple interlinked and dose-dependent pathways, is a well investigated process. In addition to the sequence of the genome, the contribution of epigenetics to cardiogenesis is increasingly recognized. Significant progress has been made dissecting the epigenome of the heart and identified associations with cardiovascular diseases. The role of epigenetic regulation in cardiac development/cardiogenesis, using tissue and animal models, has been well reviewed. Here, we curate the current literature based on studies in humans, which have revealed associated and/or causative epigenetic factors implicated in CHD. We sought to summarize the current knowledge on the functional role of epigenetics in cardiogenesis as well as in distinct CHDs, with an aim to provide scientists and clinicians an overview of the abnormal cardiogenic pathways affected by epigenetic mechanisms, for a better understanding of their impact on the developing fetal heart, particularly for readers interested in CHD research.

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