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Tytuł pozycji:

Circular RNA circTUBGCP3 Is Up-Regulated and Promotes Cell Proliferation, Migration and Survivability via Sponge mir-30b in Osteosarcoma

Tytuł :
Circular RNA circTUBGCP3 Is Up-Regulated and Promotes Cell Proliferation, Migration and Survivability via Sponge mir-30b in Osteosarcoma
Autorzy :
Xu Y
Yao T
Huang K
Liu G
Huang Y
Gao J
Ye H
Shen S
Ma J
Pokaż więcej
Temat :
osteosarcoma
circular rna
circtubgcp3
mir-30b
vimentin
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło :
OncoTargets and Therapy, Vol Volume 13, Pp 3729-3737 (2020)
Wydawca :
Dove Medical Press, 2020.
Rok publikacji :
2020
Kolekcja :
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1178-6930
Relacje :
https://www.dovepress.com/circular-rna-circtubgcp3-is-up-regulated-and-promotes-cell-proliferati-peer-reviewed-article-OTT; https://doaj.org/toc/1178-6930
Dostęp URL :
https://doaj.org/article/489cb2ea52b344b3856377c4b82a4a37
Numer akcesji :
edsdoj.489cb2ea52b344b3856377c4b82a4a37
Czasopismo naukowe
Yining Xu,1,2,* Teng Yao,2,* Kangmao Huang,2,* Gang Liu,2 Yizhen Huang,2 Jun Gao,2 Huali Ye,2 Shuying Shen,2 Jianjun Ma1,2 1Shaoxing University School of Medicine, Shaoxing, Zhejiang 312000, People’s Republic of China; 2Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine & Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuying ShenDepartment of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine & Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang 310000, People’s Republic of ChinaTel +0086-057186002200Fax +0086-057186044817Email 11207057@zju.edu.cnJianjun MaShaoxing University School of Medicine, Shaoxing, Zhejiang 312000, People’s Republic of ChinaEmail sealteam@zju.edu.cnPurpose: Prevailing evidences have demonstrated that circular RNAs (circRNAs) are closely associated with various stages of carcinogenesis. However, very few studies have delineated the specific mechanism of association between circRNAs and osteosarcoma (OS). It offers a novel insight that circRNAs can be explored as a potential therapeutic strategy for OS.Materials and Methods: In this study, circTUBGCP3 was chosen from the existing reported circRNA microarray data obtained from OS cell lines and normal bone cells. Subsequently, qRT-PCR was performed to evaluate the expression level of circTUBGCP3 in OS samples and cell lines. Functional assays were conducted to estimate the impact of circTUBGCP3 on human OS cells proliferation, vitality, survivability, and migration. Western blot, luciferase reporter and in vivo tumorigenesis assays were performed to analyze the signaling pathways underlying the interaction of circTUBGCP3, miR-30b, and Vimentin.Results: The data indicate that circTUBGCP3 may act as a sponge of miR-30b that further alters the expression of Vimentin, and promotes the proliferation and metastatic properties of OS cells.Conclusion: circTUBGCP3 serves as a tumor promoter in tumorigenesis by increasing the possibilities of OS initiation and proliferation.Keywords: osteosarcoma, circular RNA, circTUBGCP3, miR-30b, Vimentin
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