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Tytuł pozycji:

Screening History in Vaginal Precancer and Cancer: A Retrospective Study of 2131 Cases in China

Tytuł:
Screening History in Vaginal Precancer and Cancer: A Retrospective Study of 2131 Cases in China
Autorzy:
Zhang L
Wang Q
Zhang H
Xie Y
Sui L
Cong Q
Temat:
cytology
human papilloma virus
colposcopy
vaginal intraepithelial neoplasia
vaginal cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło:
Cancer Management and Research, Vol Volume 13, Pp 8855-8863 (2021)
Wydawca:
Dove Medical Press, 2021.
Rok publikacji:
2021
Kolekcja:
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1179-1322
Relacje:
https://www.dovepress.com/screening-history-in-vaginal-precancer-and-cancer-a-retrospective-stud-peer-reviewed-fulltext-article-CMAR; https://doaj.org/toc/1179-1322
Dostęp URL:
https://doaj.org/article/a4d1232efc684151a9abf34415a07221  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.4d1232efc684151a9abf34415a07221
Czasopismo naukowe
Lu Zhang, Qing Wang, Hongwei Zhang, Yu Xie, Long Sui, Qing Cong Medical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Qing Cong; Long SuiMedical Center of Diagnosis and Treatment for Cervical Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People’s Republic of ChinaTel +86 15900798278; +86 13801788118Fax +86 21 33189900Email 151468770@qq.com; suilong@fudan.edu.cnPurpose: To examine the screening history of vaginal intraepithelial neoplasia (VaIN) and vaginal cancer.Patients and Methods: We included women with histologically confirmed VaIN or vaginal cancer by colposcopy-directed biopsy between 1 January 2019 and 31 December 2019. The results of cytology, hrHPV, colposcopic examination and history of hysterectomy were retrospectively analysed.Results: A total of 26,432 colposcopies were performed during the study period, among which 2131 women (1835 [86.1%] with VaIN 1; 268 [12.6%] with VaIN 2/3; and 28 [1.3%] with vaginal cancer) were retrospectively studied. hrHPV test positivity was significantly higher than that of cytology for VaIN 1 (84.4% vs 67.3%; P < 0.001) and VaIN 2/3 (92.0% vs 79.9%; P < 0.001) but not for vaginal cancer (84.6% vs 78.6%; P = 0.73). Additionally, the concordance rates for colposcopic impression were 79.5%, 54.5%, and 92.8% for VaIN1, VaIN2/3, and vaginal cancer, respectively. All 372 patients had a history of hysterectomy, and 81.0% (282/348) of indications were related to cervical precancer and cancer. Although cytology test positivity was significantly higher in patients with hysterectomy than in patients without hysterectomy (76.2% vs 67.5%; P < 0.001), cytology combined with hrHPV can help to detect more than 95% of VaIN and vaginal cancer cases in both groups (96.2% for patients with hysterectomy and 96.5% for patients without hysterectomy).Conclusion: VaIN and vaginal cancer are not rare diseases. Although cytology was sensitive (67.5%– 76.2%) for detecting vaginal lesions regardless of hysterectomy, cytology combined with hrHPV improves detection accuracy up to 95% in both groups.Keywords: cytology, human papilloma virus, colposcopy, vaginal intraepithelial neoplasia, vaginal cancer

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