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Tytuł pozycji:

Developmental status of human immunodeficiency virus-exposed uninfected premature infants compared with premature infants who are human immunodeficiency virus unexposed and uninfected

Tytuł:
Developmental status of human immunodeficiency virus-exposed uninfected premature infants compared with premature infants who are human immunodeficiency virus unexposed and uninfected
Autorzy:
Charne Cox
Joanne Potterton
Samantha Rosie
Temat:
hiv exposed
premature
development
infants
neonatal complications
neonatal jaundice
Therapeutics. Pharmacology
RM1-950
Źródło:
South African Journal of Physiotherapy, Vol 76, Iss 1, Pp e1-e6 (2020)
Wydawca:
AOSIS, 2020.
Rok publikacji:
2020
Kolekcja:
LCC:Therapeutics. Pharmacology
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
0379-6175
2410-8219
Relacje:
https://sajp.co.za/index.php/sajp/article/view/1401; https://doaj.org/toc/0379-6175; https://doaj.org/toc/2410-8219
DOI:
10.4102/sajp.v76i1.1401
Dostęp URL:
https://doaj.org/article/4e6ef06ae8564028a509e915ebd3b7fb  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.4e6ef06ae8564028a509e915ebd3b7fb
Czasopismo naukowe
Background: There is growing concern about the developmental outcome of infants exposed to HIV in utero. HIV-infected women are at greater risk of premature delivery which poses a further developmental risk factor. Objectives: To determine whether there is a difference between the development of premature infants born at 28–37 weeks gestational age that are HIV exposed but uninfected (HEU) compared with HIV-unexposed uninfected infants (HUU). Method: A cross-sectional study was conducted in a Johannesburg state hospital. Thirty HEU and 30 HUU infants, aged between 16 days and six months, were assessed using the Bayley Scales of Infant and Toddler Development III. Results: The two groups were well matched for gestational age and birth weight; however, more HUU infants presented with neonatal complications. HUU infants had lower developmental scores than HEU infants in the language (p = 0.003) and motor (p = 0.037) subscales. Expressive language was more affected in the HUU infants (p = 0.001), and fine (p = 0.001) and gross motor (p = 0.03) were affected as well. HUU infants with neonatal complications such as meningitis (p = 0.02) and neonatal jaundice (NNJ) (p = 0.01) are more likely to present with language and motor delay. Conclusion: Meningitis and NNJ have more impact on infant development than in-utero HIV and ARV exposure. Clinical implications: It is important for all premature infants to be screened regularly in order to diagnose developmental delays early so as to ensure early intervention and improved quality of life.
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