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Tytuł:
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Chemoprotective effect of the alkaloid extract of Melocactus bellavistensis against colon cancer induced in rats using 1,2-dimethylhydrazine
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Autorzy:
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Karla Ríos-León
Cesar Fuertes-Ruiton
Jorge Arroyo
Julio Ruiz
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Temat:
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cáncer de colon, melocactus bellavistensis, alcaloides, 1,2-dimetilhidrazina, toxicidad, efecto quimioprotector
Medicine
Medicine (General)
R5-920
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Źródło:
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Revista Peruana de Medicina Experimental y Salud Pública, Vol 34, Iss 1, Pp 70-5 (2017)
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Wydawca:
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Instituto Nacional de Salud, 2017.
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Rok publikacji:
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2017
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Kolekcja:
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LCC:Medicine
LCC:Medicine (General)
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Typ dokumentu:
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article
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Opis pliku:
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electronic resource
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Język:
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Spanish; Castilian
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ISSN:
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1726-4634
1726-4642
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Relacje:
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https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/2768; https://doaj.org/toc/1726-4634; https://doaj.org/toc/1726-4642
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DOI:
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10.17843/rpmesp.2017.341.2768
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Dostęp URL:
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https://doaj.org/article/5155fdd6c2804d96a5db73e3c294adc5  Link otwiera się w nowym oknie
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Numer akcesji:
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edsdoj.5155fdd6c2804d96a5db73e3c294adc5
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Objectives. To determine the toxicity and chemoprotective effect of the alkaloid extract of Melocactus bellavistensis against colon cancer induced in rats using 1,2-dimethylhydrazine (DMH). Materials and methods. The alkaloid extract was obtained from the fleshy part of M. bellavistensis, and an acute toxicity test was then carried out on 30 mice of the Balb C57 strain. To assess its chemoprotective effect, colon cancer was induced in 45 Holtzman rats using DMH according to the following experimental design: one control group received 2 mL/kg sodium polysorbate, and four groups received 20 mg/kg DMH plus 0, 1, 5, or 10 mg/kg M. bellavistensis alkaloid extract. Results. With a sample of 5 g of alkaloid extract, an LD50 greater than 1000 mg/mL was determined in the acute toxicity test. Histological indicators revealed that the 5 and 10 mg/kg doses had significant anti-tumor activity with 100% neoplasia inhibition against DMHinduced colon cancer in rats. Conclusions. Under experimental conditions, the alkaloid extract of M. bellavistensis has a chemoprotective effect against DMH-induced colon cancer in rats.