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Tytuł pozycji:

Association between apoptosis inhibitor of macrophage and microsatellite instability status in colorectal cancer

Tytuł:
Association between apoptosis inhibitor of macrophage and microsatellite instability status in colorectal cancer
Autorzy:
Wen-juan Huang
Xin Wang
Meng-lin Zhang
Li Li
Rui-tao Wang
Temat:
Apoptosis inhibitor of macrophage
Microsatellite instability
Colorectal cancer
Diseases of the digestive system. Gastroenterology
RC799-869
Źródło:
BMC Gastroenterology, Vol 20, Iss 1, Pp 1-7 (2020)
Wydawca:
BMC, 2020.
Rok publikacji:
2020
Kolekcja:
LCC:Diseases of the digestive system. Gastroenterology
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1471-230X
Relacje:
http://link.springer.com/article/10.1186/s12876-020-01520-8; https://doaj.org/toc/1471-230X
DOI:
10.1186/s12876-020-01520-8
Dostęp URL:
https://doaj.org/article/6298de6cf732472e9bfbe1c582d4e9ff  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.6298de6cf732472e9bfbe1c582d4e9ff
Czasopismo naukowe
Abstract Background The microsatellite instability (MSI) in colorectal cancer (CRC) has a more favorable clinical outcome and is characterized by highly upregulated expression of various immunological checkpoints than microsatellite stable (MSS) tumors. Apoptosis inhibitor of macrophage (AIM) is a circulating protein and circulates throughout the body to remove cellular debris. The aim of this study was to evaluate the association between MSI status and AIM levels in CRC patients. Methods In this study, we evaluated the levels of AIM by Enzyme Linked Immuno-Sorbent Assay (ELISA) in serum of 430 CRC patients. All patients’ clinical and laboratory characteristics at initial diagnosis were collected. The relationship between AIM levels and MSI status was examined. Results 64 patients (14.9%) were identified as having MSI-H (high-frequency MSI) and 366 casess (85.1%) having MSS. Patients with an MSI-H phenotype had lower AIM levels compared with MSS patients. Moreover, AIM levels were correlated with histological type and MSI status. Logistic regression analysis revealed that decreased AIM levels were independently associated with MSI-H phenotype after adjusting confounding factors. Conclusion Reduced AIM levels are associated with MSI-H subtyping of CRC. Further research on the involvement of AIM in MSI-H CRC is needed.

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