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Tytuł pozycji:

Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM

Tytuł:
Association Analysis of Insulin Resistance and Osteoporosis Risk in Chinese Patients with T2DM
Autorzy:
Wang X
Jiang L
Shao X
Temat:
type 2 diabetes mellitus
insulin resistance
osteoporosis
bone mineral density
homeostasis model assessment for insulin resistance
Therapeutics. Pharmacology
RM1-950
Źródło:
Therapeutics and Clinical Risk Management, Vol Volume 17, Pp 909-916 (2021)
Wydawca:
Dove Medical Press, 2021.
Rok publikacji:
2021
Kolekcja:
LCC:Therapeutics. Pharmacology
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1178-203X
Relacje:
https://www.dovepress.com/association-analysis-of-insulin-resistance-and-osteoporosis-risk-in-ch-peer-reviewed-fulltext-article-TCRM; https://doaj.org/toc/1178-203X
Dostęp URL:
https://doaj.org/article/63c6464b70424e0b8a0c7ec37eef665b  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.63c6464b70424e0b8a0c7ec37eef665b
Czasopismo naukowe
Xinshui Wang,1 Lijuan Jiang,2 Xiaonan Shao3 1Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 2Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of China; 3Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaCorrespondence: Lijuan JiangDepartment of Clinical Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People’s Republic of ChinaTel +86-0-13776885831Fax +86-0519-86621235Email czyyjlj@126.comBackground: To explore the relationship between insulin resistance and osteoporosis risk in Chinese patients with type 2 diabetes mellitus (T2DM).Methods: A total of 234 T2DM patients were retrospectively analyzed, and their lumbar bone mineral density (BMD) and insulin resistance using C-peptide-based homeostasis model of insulin resistance [HOMA-IR (CP)] were assessed. Univariate and multivariable logistic regression methods were used to evaluate the association between HOMA-IR (CP) and osteoporosis, and subgroup analysis was performed on female and male patients.Results: After fully adjusting the covariates, the association between HOMA-IR (CP) and osteoporosis was only significant in female patients (P = 0.022); the interaction effect with gender was significant (P for interaction < 0.05). Curve fitting showed that the relationship between HOMA-IR (CP) and osteoporosis in women was nonlinear. When HOMA-IR (CP) is < 4.00, its effect on osteoporosis was not significant (P = 0.474); when HOMA-IR (CP) is > 4.00, the risk of osteoporosis increased significantly, with OR = 26.88 (95% CI: 2.75– 262.69, P = 0.005). The relationship between insulin resistance and osteoporosis risk in T2DM patients is significantly affected by gender.Conclusion: The higher the degree of insulin resistance in female patients, the greater the risk of osteoporosis, but the two are not linearly associated.Keywords: type 2 diabetes mellitus, insulin resistance, osteoporosis, bone mineral density, homeostasis model assessment for insulin resistance
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