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Title of the item:

Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizuma

Title :
Case report of polymyalgia rheumatica in a male patient with three different neoplasms treated with pembrolizuma
Authors :
F.M. Perrotta
S. Scriffignano
M. Fatica
M. Specchia
E. Lubrano
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Subject Terms :
Pembrolizumab
polymyalgia rheumatica
immune-checkpoint inhibitors.
Medicine
Internal medicine
RC31-1245
Source :
Reumatismo, Vol 72, Iss 3 (2020)
Publisher :
PAGEPress Publications, 2020.
Publication Year :
2020
Collection :
LCC:Medicine
LCC:Internal medicine
Document Type :
article
File Description :
electronic resource
Language :
English
Italian
ISSN :
0048-7449
2240-2683
Relation :
https://www.reumatismo.org/index.php/reuma/article/view/1297; https://doaj.org/toc/0048-7449; https://doaj.org/toc/2240-2683
DOI :
10.4081/reumatismo.2020.1297
Access URL :
https://doaj.org/article/ded68aa061c44417825e5926d6a831f0
Accession Number :
edsdoj.68aa061c44417825e5926d6a831f0
Academic Journal
In this manuscript we aim to describe a particular case of a 63 years-old man who developed three different malignancies (one was a rare case of breast cancer) among nearly five years. In particular, for the diagnosis of melanoma, he was treated with pembrolizumab, a PD-1 inhibitor. After few months of treatment with pembrolizumab, the patient reported the onset of musculoskeletal symptoms such as inflammatory pain at the shoulders and morning stiffness, with raised CRP and ESR and imaging evidence of bursitis and tenosynovitis. A polymyalgia-like syndrome was diagnosed. Understanding if these manifestations are linked to the use of pembrolizumab or to a paraneoplastic syndrome, and how to manage the patient, was the real challenge.

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