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Tytuł pozycji:

In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid

Tytuł :
In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid
Autorzy :
Wang YH
Qu T
Wang XL
Yang RP
Pokaż więcej
Temat :
salvianolic acid sustained-release microcapsule
marine polysaccharides
chitosan
salvia miltiorrhiza. dan phenolic acid b
Therapeutics. Pharmacology
RM1-950
Źródło :
Drug Design, Development and Therapy, Vol Volume 15, Pp 1623-1631 (2021)
Wydawca :
Dove Medical Press, 2021.
Rok publikacji :
2021
Kolekcja :
LCC:Therapeutics. Pharmacology
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1177-8881
Relacje :
https://www.dovepress.com/in-vitro-preparation-and-evaluation-of-sustained-release-microcapsules-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881
Dostęp URL :
https://doaj.org/article/6dea3bc7a0bb4a64b6bf79ba7a0c8130
Numer akcesji :
edsdoj.6dea3bc7a0bb4a64b6bf79ba7a0c8130
Czasopismo naukowe
Yun-Hong Wang,1 Tong Qu,2 Xue-Lian Wang,3 Rong-Ping Yang3 1Chongqing Academy of Chinese Materia Medica, Chongqing, 400065, People’s Republic of China; 2Shaanxi University of Chinese Medicine, Xianyang, 712046, People’s Republic of China; 3Department of Pharmacy College, Southwest University, Chongqing, 400715, People’s Republic of ChinaCorrespondence: Rong-Ping YangDepartment of Pharmacy College, Southwest University, No. 2 of Tiansheng Street, Beibei District, Chongqing, 400715, People’s Republic of ChinaTel +86 023-68251225Fax +86 023-68251225Email yangrongping1119@163.comObjective: This study aims to investigate the preparation of sustained-release microcapsules of salvianolic acid.Methods: The stability of salvianolic acid microcapsules was improved, and the time of action was prolonged in the present study. This was prepared using the spray-drying method, with chitosan as the carrier. In the preparation process, the prescription and process were optimized by L9 (34) using an orthogonal design, with yield and drug loading as indexes, in order to obtain optimum conditions.Results: The optimal process and prescription for the preparation of salvianolic acid microcapsules were found to be as follows: mass concentration of chitosan, 1.5%; mass ratio of salvianolic acid to chitosan, 1:3; inlet air temperature, 190°C; and peristaltic pump speed, 300 mL·h-1. The surface of the microcapsules was round, the drug loading was 25.99% ± 2.14%, the yield was 51.88% ± 2.84%, the entrapment efficiency was 86.21% ± 2.89%, and the average particle size was 105.6 ± 2.56 nm. The microcapsules in vitro had certain sustained release characteristics. The internally fitted first-order release model equation was ln(1-Q) = − 0.236 t + 4.591 7, r = 0.920. In addition, the results of differential scanning calorimetry show that the properties of salvianolic acid were not changed by the microcapsules.Conclusion: Sustained-release microcapsules of salvianolic acid can be successfully prepared by adopting marine polysaccharide as a carrier.Keywords: salvianolic acid sustained-release microcapsule, marine polysaccharides, chitosan, Salvia miltiorrhiza, salvianolic acid B

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