Effect of radical lymphadenectomy in colorectal cancer with para-aortic lymph node metastasis: a systematic review and meta-analysis

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Tytuł:: Effect of radical lymphadenectomy in colorectal cancer with para-aortic lymph node metastasis: a systematic review and meta-analysis
Autorzy:: Pengyue Zhao
Xingpeng Yang
Yang Yan
Jiaqi Yang
Songyan Li
Xiaohui Du
Temat:: Colorectal cancer
PALNM
Survival
Complication
Meta-analysis
Surgery
RD1-811
Źródło:: BMC Surgery, Vol 22, Iss 1, Pp 1-11 (2022)
Wydawca:: BMC, 2022.
Rok publikacji:: 2022
Kolekcja:: LCC:Surgery
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 1471-2482
Relacje:: https://doaj.org/toc/1471-2482
DOI:: 10.1186/s12893-022-01631-x
Dostęp URL:: https://doaj.org/article/734e6dc00c404967b4bdee9c0281bfe5 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.734e6dc00c404967b4bdee9c0281bfe5
: Czasopismo naukowe

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Abstract Background Colorectal cancer (CRC) with para-aortic lymph node metastasis (PALNM) is an intractable clinical situation, and the role of radical lymphadenectomy in the treatment of CRC with PALNM is still controversial. The aim of the current system review and meta-analysis is to evaluate the clinical efficacy and safety of radical lymphadenectomy in CRC patients with PALAN. Methods We performed a systematic search of PubMed, Embase, Cochrane Library and other online databases up to 31 October 2021. The clinical data including overall survival and postoperative complications were screened and analyzed after data extraction. Odds ratios (ORs) were applied to analyze these dichotomous outcomes with a fixed effects model. Results A total of 7 available retrospective clinical studies involving 327 patients were finally included. CRC patients with PALNM who underwent radical lymphadenectomy showed significantly overall survival (OR: 6.80, 95% CI: 3.46–13.38, P

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