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Tytuł pozycji:

Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d’Ivoire: a SCORE study protocol

Tytuł:
Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d’Ivoire: a SCORE study protocol
Autorzy:
Yves-Nathan T. Tian-Bi
Mamadou Ouattara
Stefanie Knopp
Jean T. Coulibaly
Eveline Hürlimann
Bonnie Webster
Fiona Allan
David Rollinson
Aboulaye Meïté
Nana R. Diakité
Cyrille K. Konan
Eliézer K. N’Goran
Jürg Utzinger
Temat:
Bulinus spp.
Chemical snail control
Côte d’Ivoire
Mass drug administration
Niclosamide
Praziquantel
Public aspects of medicine
RA1-1270
Źródło:
BMC Public Health, Vol 18, Iss 1, Pp 1-12 (2018)
Wydawca:
BMC, 2018.
Rok publikacji:
2018
Kolekcja:
LCC:Public aspects of medicine
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1471-2458
Relacje:
http://link.springer.com/article/10.1186/s12889-018-5044-2; https://doaj.org/toc/1471-2458
DOI:
10.1186/s12889-018-5044-2
Dostęp URL:
https://doaj.org/article/a790d7176f1e44bab64c561eb1972ba7  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.790d7176f1e44bab64c561eb1972ba7
Czasopismo naukowe
Abstract Background To achieve a world free of schistosomiasis, the objective is to scale up control and elimination efforts in all endemic countries. Where interruption of transmission is considered feasible, countries are encouraged to implement a comprehensive intervention package, including preventive chemotherapy, information, education and communication (IEC), water, sanitation and hygiene (WASH), and snail control. In northern and central Côte d’Ivoire, transmission of Schistosoma haematobium is seasonal and elimination might be achieved. In a cluster-randomised trial, we will assess different treatment schemes to interrupt S. haematobium transmission and control soil-transmitted helminthiasis over a 3-year period. We will compare the impact of (i) arm A: annual mass drug administration (MDA) with praziquantel and albendazole before the peak schistosomiasis transmission season; (ii) arm B: annual MDA after the peak schistosomiasis transmission season; (iii) arm C: two yearly treatments before and after peak schistosomiasis transmission; and (iv) arm D: annual MDA before peak schistosomiasis transmission, coupled with chemical snail control using niclosamide. Methods/design The prevalence and intensity of S. haematobium and soil-transmitted helminth infections will be assessed using urine filtration and Kato-Katz thick smears, respectively, in six administrative regions in northern and central parts of Côte d’Ivoire. Once a year, urine and stool samples will be collected and examined from 50 children aged 5–8 years, 100 children aged 9–12 years and 50 adults aged 20–55 years in each of 60 selected villages. Changes in S. haematobium and soil-transmitted helminth prevalence and intensity will be assessed between years and stratified by intervention arm. In the 15 villages randomly assigned to intervention arm D, intermediate host snails will be collected three times per year, before niclosamide is applied to the selected freshwater bodies. The snail abundance and infection rates over time will allow drawing inference on the force of transmission. Discussion This cluster-randomised intervention trial will elucidate whether in an area with seasonal transmission, the four different treatment schemes can interrupt S. haematobium transmission and control soil-transmitted helminthiasis. Lessons learned will help to guide schistosomiasis control and elimination programmes elsewhere in Africa. Trial registration ISRCTN ISRCTN10926858. Registered 21 December 2016. Retrospectively registered.
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