Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Functionalizing DNA nanostructures with natural cationic amino acids

Tytuł:
Functionalizing DNA nanostructures with natural cationic amino acids
Autorzy:
Dong Wang
Chunfa Chen
Qian Liu
Qianwen Zhao
Di Wu
Yue Yuan
Chaowang Huang
Xiaorong Sun
Chunji Huang
David Tai Leong
Guansong Wang
Hang Qian
Temat:
DNA nanostructures
Noncanonical DNA self-Assembly
Amino acids
Isothermal self-assembly
Materials of engineering and construction. Mechanics of materials
TA401-492
Biology (General)
QH301-705.5
Źródło:
Bioactive Materials, Vol 6, Iss 9, Pp 2946-2955 (2021)
Wydawca:
KeAi Communications Co., Ltd., 2021.
Rok publikacji:
2021
Kolekcja:
LCC:Materials of engineering and construction. Mechanics of materials
LCC:Biology (General)
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
2452-199X
Relacje:
http://www.sciencedirect.com/science/article/pii/S2452199X21000724; https://doaj.org/toc/2452-199X
DOI:
10.1016/j.bioactmat.2021.02.012
Dostęp URL:
https://doaj.org/article/ee7969f6f8074b16a174f900c17df7e6  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.7969f6f8074b16a174f900c17df7e6
Czasopismo naukowe
Complexing self-assembled DNA nanostructures with various functional guest species is the key to unlocking new and exciting biomedical applications. Cationic guest species not only induce magnesium-free DNA to self-assemble into defined structures but also endow the final complex nanomaterials with new properties. Herein, we propose a novel strategy that employs naturally occurring cationic amino acids to induce DNA self-assembly into defined nanostructures. Natural l-arginine and l-lysine can readily induce the assembly of tile-based DNA nanotubes and DNA origami sheets in a magnesium-free manner. The self-assembly processes are demonstrated to be pH- and concentration-dependent and are achieved at constant temperatures. Moreover, the assembled DNA/amino acid complex nanomaterials are stable at a physiological temperature of 37 °C. Substituting l-arginine with its D form enhances its serum stability. Further preliminary examination of this complex nanomaterial platform for biomedical applications indicates that DNA/amino acids exhibit distinct cellular uptake behaviors compared with their magnesium-assembled counterparts. The nanomaterial mainly clusters around the cell membrane and might be utilized to manipulate molecular events on the membrane. Our study suggests that the properties of DNA nanostructures can be tuned by complexing them with customized guest molecules for a designed application. The strategy proposed herein might be promising to advance the biomedical applications of DNA nanostructures.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies