Diagnostic and prognostic values of pyroptosis-related genes for the hepatocellular carcinoma

Tytuł:: Diagnostic and prognostic values of pyroptosis-related genes for the hepatocellular carcinoma
Autorzy:: Mindan Xing
Jia Li
Temat:: Hepatocellular carcinoma
Pyroptosis
Prognostic markers
Diagnosis markers
Risk model
Computer applications to medicine. Medical informatics
R858-859.7
Biology (General)
QH301-705.5
Źródło:: BMC Bioinformatics, Vol 23, Iss 1, Pp 1-17 (2022)
Wydawca:: BMC, 2022.
Rok publikacji:: 2022
Kolekcja:: LCC:Computer applications to medicine. Medical informatics
LCC:Biology (General)
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 1471-2105
Relacje:: https://doaj.org/toc/1471-2105
DOI:: 10.1186/s12859-022-04726-7
Dostęp URL:: https://doaj.org/article/7f27c883beb0499799e5397900fdc7e0 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.7f27c883beb0499799e5397900fdc7e0
: Czasopismo naukowe

Pełny tekst

Abstract Background Due to the high heterogeneity, the early diagnosis and prognostic prediction of hepatic cellular cancer (HCC) is challenging. In this study, we explored the diagnostic and prognostic value of pyroptosis-related genes (PRGs) in HCC. We downloaded the mRNA expression profiles of HCC and the corresponding clinical data from the TCGA and ICGC databases. Fifty-one PRGs were extracted from Genecards, MsigDB, and relevant literature. The area under the receiver operating characteristic (AUC) was used to explore the diagnostic value of the PRGs. Results The results revealed that BAK1, BAX, CHMP2A, CHMP4C, CHMP6, GSDMC, and GSDMD had higher diagnostic values for HCC (AUCs > 0.8, P

Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Informacja