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Tytuł pozycji:

Hepatic Cyp1a2 Expression Reduction during Inflammation Elicited in a Rat Model of Intermittent Hypoxia

Tytuł:
Hepatic Cyp1a2 Expression Reduction during Inflammation Elicited in a Rat Model of Intermittent Hypoxia
Autorzy:
Li-Xia Shi
Xing Wang
Qi Wu
Xin Sun
Zhen Wan
Li Li
Kuan Li
Xue Li
Yu Li
Qiu-Yang Zhang
Jun-Ping Wu
Huai-Yong Chen
Temat:
Cytochrome P450
Glucocorticoid Receptor
Inflammation
Intermittent Hypoxia
Nuclear Factor-κB
Medicine
Źródło:
Chinese Medical Journal, Vol 130, Iss 21, Pp 2585-2590 (2017)
Wydawca:
Wolters Kluwer, 2017.
Rok publikacji:
2017
Kolekcja:
LCC:Medicine
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
0366-6999
Relacje:
http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=21;spage=2585;epage=2590;aulast=Shi; https://doaj.org/toc/0366-6999
DOI:
10.4103/0366-6999.217084
Dostęp URL:
https://doaj.org/article/80a2e7f0c40e4635a24c71e29dafc2dc  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.80a2e7f0c40e4635a24c71e29dafc2dc
Czasopismo naukowe
Background: Intermittent hypoxia (IH) is a key element of obstructive sleep apnea (OSA) that can lead to disorders in the liver. In this study, IH was established in a rat model to examine its effects on the expression of hepatic cytochrome P450 (CYP) and CYP regulators, including nuclear receptors. Methods: Hematoxylin and eosin staining was conducted to analyze the general pathology of the liver of rats exposed to IH. The messenger RNA (mRNA) expression levels of inflammatory cytokines, CYPs, nuclear factor-κB (NF-κB), and nuclear factors in the liver were measured by quantitative reverse transcription polymerase chain reaction. Results: We found inflammatory infiltrates in the liver of rats exposed to IH. The mRNA expression level of interleukin-1beta was increased in the liver of the IH-exposed rats (0.005 ± 0.001 vs. 0.038 ± 0.008, P = 0.042), whereas the mRNA expression level of Cyp1a2 was downregulated (0.022 ± 0.002 vs. 0.0050 ± 0.0002, P = 0.029). The hepatic level of transcription factor NF-κB was also reduced in the IH group relative to that in the control group, but the difference was not statistically significant and was parallel to the expression of the pregnane X receptor and constitutive androstane receptor. However, the decreased expression of the glucocorticoid receptor upon IH treatment was statistically significant (0.056 ± 0.012 vs. 0.032 ± 0.005, P = 0.035). Conclusions: These results indicate a decrease in expression of hepatic CYPs and their regulator GR in rats exposed to IH. Therefore, this should be noted for patients on medication, especially those on drugs metabolized via the hepatic system, and close attention should be paid to the liver function of patients with OSA-associated IH.

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