Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

The effect of anxiety on brain activation patterns in response to inspiratory occlusions: an fMRI study

Tytuł :
The effect of anxiety on brain activation patterns in response to inspiratory occlusions: an fMRI study
Autorzy :
Pei-Ying S. Chan
Yu-Ting Wu
Ai-Ling Hsu
Chia-Wei Li
Changwei W. Wu
Andreas von Leupoldt
Shih-Chieh Hsu
Pokaż więcej
Temat :
Medicine
Science
Źródło :
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Wydawca :
Nature Publishing Group, 2019.
Rok publikacji :
2019
Kolekcja :
LCC:Medicine
LCC:Science
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
2045-2322
Relacje :
http://link.springer.com/article/10.1038/s41598-019-51396-2; https://doaj.org/toc/2045-2322
DOI :
10.1038/s41598-019-51396-2
Dostęp URL :
https://doaj.org/article/819bfed8eaa74d53b8dfe14e7bec6939
Numer akcesji :
edsdoj.819bfed8eaa74d53b8dfe14e7bec6939
Czasopismo naukowe
Abstract Respiratory sensations such as breathlessness are prevalent in many diseases and are amplified by increased levels of anxiety. Cortical activation in response to inspiratory occlusions in high- and low-anxious individuals was found different in previous studies using the respiratory-related evoked potential method. However, specific brain areas showed different activation patterns remained unknown in these studies. Therefore, the purpose of this study was to compare cortical and subcortical neural substrates of respiratory sensation in response to inspiratory mechanical occlusion stimuli between high- and low-anxious individuals using functional magnetic resonance imaging (fMRI). In addition, associations between brain activation patterns and levels of anxiety, and breathlessness were examined. Thirty-four (17 high- and 17 low-anxious) healthy non-smoking adults with normal lung function completed questionnaires on anxiety (State Trait Anxiety Inventory - State), and participated in a transient inspiratory occlusion fMRI experiment. The participants breathed with a customized face-mask while respiration was repeatedly interrupted by a transient inspiratory occlusion of 150-msec, delivered every 2 to 4 breaths. Breathlessness was assessed by self-report. At least 32 occluded breaths were collected for data analysis. The results showed that compared to the low-anxious group, the high-anxious individuals demonstrated significantly greater neural activations in the hippocampus, insula, and middle cingulate gyrus in response to inspiratory occlusions. Moreover, a significant relationship was found between anxiety levels and activations of the right inferior parietal gyrus, and the right precuneus. Additionally, breathlessness levels were significantly associated with activations of the bilateral thalamus, bilateral insula and bilateral cingulate gyrus. The above evidences support stronger recruitment of emotion-related cortical and subcortical brain areas in higher anxious individuals, and thus these areas play an important role in respiratory mechanosensation mediated by anxiety.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies