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Tytuł pozycji:

Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

Tytuł :
Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer
Autorzy :
Francisco Bárbara Abreu Barros
Agnes Assao
Natália Galvão Garcia
Suely Nonogaki
André Lopes Carvalho
Fernando Augusto Soares
Luiz Paulo Kowalski
Denise Tostes Oliveira
Pokaż więcej
Temat :
Oral cancer
Squamous cell carcinoma
Podoplanin
Moesin
Biomarkers
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło :
BMC Cancer, Vol 18, Iss 1, Pp 1-8 (2018)
Wydawca :
BMC, 2018.
Rok publikacji :
2018
Kolekcja :
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1471-2407
Relacje :
http://link.springer.com/article/10.1186/s12885-017-3914-0; https://doaj.org/toc/1471-2407
DOI :
10.1186/s12885-017-3914-0
Dostęp URL :
https://doaj.org/article/84b69827be80459496956250f617bd14
Prawa :
Journal Licence: CC BY
Numer akcesji :
edsdoj.84b69827be80459496956250f617bd14
Czasopismo naukowe
Abstract Background Moesin is a member of the ERM (ezrin, radixin and moesin) proteins that participate in cell migration and tumor invasion through transductional signals sent to actin filaments by glycoproteins, such as podoplanin. Methods This study aimed to evaluate the participation of moesin and podoplanin in the invasive tumor front of oral squamous cell carcinomas, and their influence on patients’ prognosis. Podoplanin and moesin immunoexpressions were evaluated by a semi-quantitative score method, based on the capture of 10 microscopic fields, at 400X magnification, in the invasive tumor front of oral squamous cell carcinomas. The association of moesin and podoplanin expression with clinicopathological variables was analyzed by the chi-square, or Fisher’s exact test. The 5 and 10 years survival rates were calculated by the Kaplan-Meier method and the survival curves were compared by using the log-rank test. Results The immunohistochemical expression of moesin in the invasive front of oral squamous cell carcinomas was predominantly strong, homogenously distributed on the membrane and in the cytoplasm of tumor cells. The expression of moesin was not associated with clinical, demographic and microscopic features of the patients. Otherwise, podoplanin expression by malignant epithelial cells was predominantly strong and significantly associated with radiotherapy (p = 0.004), muscular invasion (p = 0.006) and lymph node involvement (p = 0.013). Strong moesin expression was considered an unfavorable prognostic factor for patients with oral squamous cell carcinomas, clinical stage II and III (p = 0.024). Conclusions These results suggested that strong moesin expression by malignant cells may help to determine patients with oral squamous cell carcinoma and poor prognosis.
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