PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

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Tytuł:: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
Autorzy:: Tie-Gang Meng
Qian Zhou
Xue-Shan Ma
Xiao-Yu Liu
Qing-Ren Meng
Xian-Ju Huang
Hong-Lin Liu
Wen-Long Lei
Zheng-Hui Zhao
Ying-Chun Ouyang
Yi Hou
Heide Schatten
Xiang-Hong Ou
Zhen-Bo Wang
Shao-Rong Gao
Qing-Yuan Sun
Temat:: Science
Źródło:: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Wydawca:: Nature Portfolio, 2020.
Rok publikacji:: 2020
Kolekcja:: LCC:Science
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 2041-1723
Relacje:: https://doaj.org/toc/2041-1723
DOI:: 10.1038/s41467-020-20242-9
Dostęp URL:: https://doaj.org/article/880e838cf60f4e349e02ecc7127b2eb6 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.880e838cf60f4e349e02ecc7127b2eb6
: Czasopismo naukowe

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Dynamic arrangement of epigenetic modifications such as repressive H3K27 methylation is essential for zygote development. Here the authors show that establishment of genome-wide H3K27me3 in zygotes requires EZH2, that EZH1 partially compensates for EZH2 loss, and that EHMT1 is involved in H3K27me2 establishment.

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