Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E

Tytuł:: Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E
Autorzy:: Yingxian Jia
Jie Luo
Yibing Lan
Chunming Li
Linjuan Ma
Xiaoming Zhu
Fei Ruan
Jianhong Zhou
Temat:: Abnormal uterine bleeding
Human endometrium
Proteomic analysis
Primary endometrial disorder
Gynecology and obstetrics
RG1-991
Reproduction
QH471-489
Źródło:: Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-10 (2021)
Wydawca:: BMC, 2021.
Rok publikacji:: 2021
Kolekcja:: LCC:Gynecology and obstetrics
LCC:Reproduction
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 1477-7827
Relacje:: https://doaj.org/toc/1477-7827
DOI:: 10.1186/s12958-021-00713-4
Dostęp URL:: https://doaj.org/article/d881a585825944a7a32bc3da361ed87e Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.881a585825944a7a32bc3da361ed87e
: Czasopismo naukowe

Pełny tekst

Abstract Background While heavy menstrual bleeding (HMB) is a prevalent symptom among women with abnormal uterine bleeding caused by endometrial disorder (AUB-E) seeking gynecologic care, the primary endometrial disorder remains poorly understood. Methods Five human endometrial samples from women with AUB-E and the age-matched healthy women were selected, respectively. Proteins from the samples were analyzed by a linear ion trap (LTQ)-Orbitrap Elite mass spectrometer based label-free proteomic approach. The purpose protein was validated by western blot and immunohistochemistry staining. Results A total of 2353 protein groups were quantified under highly stringent criteria with a false discovery rate of

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