Circular RNA Controls Tumor Occurrence and Development via Cell Cycle Regulation

Fang Liu,* Rongfeng Qu,* Limin Yang, Guang Shi, Shuhong Hao, Chunmei Hu Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunmei Hu, Department of Hematology and Oncology, The Second Hospital of Jilin University, Ziqiang Street No. 265, Changchun, Jilin, 130041, People’s Republic of China, Tel/Fax +86043181136427, Email guyue_111@163.comAbstract: Circular RNAs (circRNAs) participate in the occurrence and development of various diseases through different mechanisms, such as by acting as a microRNA (miRNA) sponge, interacting with RNA-binding proteins, and regulating gene transcription and protein translation. For example, the abnormal expression of specific circRNAs in tumor cells can alter key regulatory factors and the cell cycle network, resulting in cell cycle disorders and the development and metastasis of tumors. Here, we summarize the mechanisms involved in the circRNA-mediated processes that lead to uncontrolled cell cycle and tumor cell proliferation. Extensive studies investigating the abnormal expression of circRNAs in different cancer types have been conducted. The unique characteristics of circRNAs and their ability to regulate the cell cycle through diverse mechanisms is extremely valuable in tumor diagnosis, treatment, and prognosis. Our review may assist in further understanding the circRNA-mediated regulation of the cell cycle in tumors and provide insights for research on circRNA-based therapeutic strategies and biological diagnosis for cancer.Keywords: circRNA, cancer, cyclins, CDKs, CKIs, p53