Potential natural immunization against atherosclerosis in hibernating bears

Szczegóły
Opis

Tytuł:: Potential natural immunization against atherosclerosis in hibernating bears
Autorzy:: Shailesh Kumar Samal
Ole Fröbert
Jonas Kindberg
Peter Stenvinkel
Johan Frostegård
Temat:: Medicine
Science
Źródło:: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Wydawca:: Nature Portfolio, 2021.
Rok publikacji:: 2021
Kolekcja:: LCC:Medicine
LCC:Science
Typ dokumentu:: article
Opis pliku:: electronic resource
Język:: English
ISSN:: 2045-2322
Relacje:: https://doaj.org/toc/2045-2322
DOI:: 10.1038/s41598-021-91679-1
Dostęp URL:: https://doaj.org/article/979b1be1e0cc42eba50336515cbe7837 Link otwiera się w nowym oknie
Numer akcesji:: edsdoj.979b1be1e0cc42eba50336515cbe7837
: Czasopismo naukowe

Pełny tekst

Abstract Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p

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