Dear user, the application need JavaScript support. Please enable JavaScript in your browser.

You are browsing as a GUEST
Title of the item:

Mycobacterium ulcerans mycolactones-fungi crosstalking

Title :
Mycobacterium ulcerans mycolactones-fungi crosstalking
Authors :
Nassim Hammoudi
Carole Cassagne
Nicholas Armstrong
Stéphane Ranque
Bernard Henrissat
Michel Drancourt
Amar Bouam
Show more
Subject Terms :
Source :
Scientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
Publisher :
Nature Publishing Group, 2019.
Publication Year :
Collection :
Document Type :
File Description :
electronic resource
Language :
Relation :;
Access URL :
Accession Number :
Academic Journal
Abstract The opportunistic pathogen Mycobacterium ulcerans, which is responsible for Buruli ulcer, synthesizes a series of plasmid-encoded macrolide exotoxins termed mycolactones. These toxins destabilize cell membranes and induce apoptosis-associated pleiotropic effects including tissue destruction, analgesic and anti-inflammatory effects. Despite its medical interest, M. ulcerans is primarily an environmental mycobacterium and the primary functions of mycolactones in the natural ecosystems are unknown. High throughput biochemical profiling findings suggested that M. ulcerans may interact with fungi. Here, we report that semi-purified and purified mycolactones significantly enhance spore germination of Scedosporium apiospermum, Fusarium equiseti and Mucor circinelloides; and that M. ulcerans mycolactones significantly attract colonies of M. circinelloides whereas no significant effect was observed on S. apiospermum and F. equiseti. These experimental results suggest that mycolactones exhibit a chemoattractant activity independent of their cytotoxicity. In natural ecosystems, M. ulcerans mycolactones may act as spore germination inducers and chemoattractants for some fungi, suggesting a novel role for this unique class of mycobacterial toxins in natural ecosystems.
Please log in to access the full text.

We use cookies to help identify your computer so we can tailor your user experience, track shopping basket contents and remember where you are in the order process.