Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Impact of the histological regression grade of the primary tumor and regional lymph nodes after neoadjuvant chemoradiotherapy on survival of patients with gastric cancer: two case reports

Tytuł:
Impact of the histological regression grade of the primary tumor and regional lymph nodes after neoadjuvant chemoradiotherapy on survival of patients with gastric cancer: two case reports
Autorzy:
V. Yu. Skoropad
D. D. Kudriavtsev
L. N. Titova
T. A. Agababjan
E. S. Zhavoronkovа
S. V. Gamayunov
D. A. Vinokurova
Temat:
рак желудка
неоадъювантная химиолучевая терапия
хирургическое лечение
клиническая регрессия
лечебный патоморфоз
выживаемость
прогноз
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło:
Сибирский онкологический журнал, Vol 19, Iss 2, Pp 132-139 (2020)
Wydawca:
Russian Academy of Sciences, Tomsk National Research Medical Center, 2020.
Rok publikacji:
2020
Kolekcja:
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
Russian
ISSN:
1814-4861
2312-3168
Relacje:
https://www.siboncoj.ru/jour/article/view/1409; https://doaj.org/toc/1814-4861; https://doaj.org/toc/2312-3168
DOI:
10.21294/1814-4861-2020-19-2-132-139
Dostęp URL:
https://doaj.org/article/e9be9be445364e7c8e599a3d1c9dafd6  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.9be9be445364e7c8e599a3d1c9dafd6
Czasopismo naukowe
Background. Stomach cancer remains one of the most common malignancies worldwide, with high incidence rates and low rates of long-term treatment outcomes. Neoadjuvant therapy currently is increasingly being considered the standard therapy for locally advanced gastric and cardioesophageal cancers. A complete pathological response of the tumor has been reported to be observed in 8-20 % of patients. However, there is no guarantee that the evidence of pathological complete response will improve the cure results in all patients, and very little is known about prognostic factors after neoadjuvant therapy.Case descriptions. Two clinical cases of locally advanced gastric cancer were described. The patients were treated with neoadjuvant chemoradiotherapy followed by D2 gastrectomy. Accelerated hyperfractionated radiotherapy (1 + 1.5 Gy/ day) to a total dose of 45 Gy at intervals of 4-5 hours was administered concurrently with chemotherapy (capecitabine: 1850 mg/m2 orally twice daily at 12-hour interval; oxaliplatin: 85 mg/m2 intravenously on days 1 and 21). Histological examination revealed complete histological regression of the primary tumor in two cases. However, in one of the cases, metastases in regional lymph nodes with grade 2 histological tumor regression were revealed. In the first case, the patient is still alive with no evidence of disease recurrence at over 6-years after treatment. In the second case, the patient died of the disease progression 3 years after treatment.Conclusion. The data obtained are consistent with the few published studies reporting that pathological complete response to neoadjuvant therapy of not only the primary tumor but also regional lymph nodes is the key point determining the effectiveness of the combined modality treatment.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies