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Tytuł pozycji:

Toll-Like Receptor 2 Is a Regulator of Circadian Active and Inactive State Consolidation in C57BL/6 Mice

Tytuł :
Toll-Like Receptor 2 Is a Regulator of Circadian Active and Inactive State Consolidation in C57BL/6 Mice
Autorzy :
Nicholas W. DeKorver
Tammy R. Chaudoin
Stephen J. Bonasera
Pokaż więcej
Źródło :
Frontiers in Aging Neuroscience, Vol 9 (2017)
Wydawca :
Frontiers Media S.A., 2017.
Rok publikacji :
2017
Kolekcja :
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Temat :
active/inactive state consolidation
sleep fragmentation
Tlr2 knockout mouse
home cage behavior
circadian behavior
movement
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1663-4365
Relacje :
http://journal.frontiersin.org/article/10.3389/fnagi.2017.00219/full; https://doaj.org/toc/1663-4365
DOI :
10.3389/fnagi.2017.00219
Dostęp URL :
https://doaj.org/article/9c62a5b9fb354fafa2651ee5db8d9aac
Prawa :
Journal Licence: CC BY
Numer akcesji :
edsdoj.9c62a5b9fb354fafa2651ee5db8d9aac
Czasopismo naukowe
Regulatory systems required to maintain behavioral arousal remain incompletely understood. We describe a previously unappreciated role that toll-like receptor 2 (Tlr2, a membrane bound pattern recognition receptor that recognizes specific bacterial, viral, and fungal peptides), contributes toward regulation of behavioral arousal. In 4–4.5 month old mice with constitutive loss of Tlr2 function (Tlr2−/− mice), we note a marked consolidation in the circadian pattern of both active and inactive states. Specifically, Tlr2−/− mice demonstrated significantly fewer but longer duration active states during the circadian dark cycle, and significantly fewer but longer duration inactive states during the circadian light cycle. Tlr2−/− mice also consumed less food and water, and moved less during the circadian light cycle. Analysis of circadian rhythms further suggested that Tlr2−/− mice demonstrated less day-to-day variability in feeding, drinking, and movement behaviors. Reevaluation of this same mouse cohort at age 8–8.5 months revealed a clear blunting of these differences. However, Tlr2−/− mice were still noted to have fewer short-duration active states during the circadian dark cycle, and continued to demonstrate significantly less day-to-day variability in feeding, drinking, and movement behaviors. These results suggest that Tlr2 function may have a role in promoting transitions between active and inactive states. Prior studies have demonstrated that Tlr2 regulates sickness behaviors including hypophagia, hyperthermia, and decreased activity. Our work suggests that Tlr2 function also evokes behavioral fragmentation, another aspect of sickness behavior and a clinically significant problem of older adults.

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