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Tytuł pozycji:

Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells

Tytuł :
Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells
Autorzy :
Cheng X
Liu Z
Shang L
Cai H
Zhang Y
Cai Y
Xu X
Hao J
Wang M
Pokaż więcej
Temat :
ESCC
MTAP
deletion
invasion
migration
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło :
OncoTargets and Therapy, Vol Volume 10, Pp 5855-5862 (2017)
Wydawca :
Dove Medical Press, 2017.
Rok publikacji :
2017
Kolekcja :
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1178-6930
Relacje :
https://www.dovepress.com/deletion-and-downregulation-of-mtap-contribute-to-the-motility-of-esop-peer-reviewed-article-OTT; https://doaj.org/toc/1178-6930
Dostęp URL :
https://doaj.org/article/c9e29a4280354819ad2d7235123f57ae
Prawa :
Journal Licence: CC BY-NC
Numer akcesji :
edsdoj.9e29a4280354819ad2d7235123f57ae
Czasopismo naukowe
Xiao-Yu Cheng,1,2 Zou Liu,1,2 Li Shang,1 Hong-Qing Cai,1 Yu Zhang,1,2 Yan Cai,1,2 Xin Xu,1,2 Jia-Jie Hao,1,2 Ming-Rong Wang1,2 1State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 2Center for Cancer Precision Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Abstract: Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, with a low 5-year overall survival rate. In previous studies, we and others have found that 9p21.3 was the most frequently deleted region in ESCC. The MTAP gene, which is located close to CDKN2A/B in 9p21.3, encodes methylthioadenosine phosphorylase. This enzyme plays an important role during the process of adenosine transfer. In the present study, we found that MTAP is deleted at the genomic level in 19.1% (64/341) of primary ESCC tumors, and decreased mRNA and protein expression were present in 31.1% (28/90) and 33.3% (6/18) of ESCCs, respectively. Further statistical analysis showed a positive correlation between deletion and decreased mRNA expression of MTAP in the ESCC tissues tested (coefficient: 0.826; P=1.17×10-23). Knockdown of MTAP expression using small interfering RNA-mediated silencing promoted the invasion and migration of ESCC cells. Also, overexpression of MATP using pcDNA3.1-MTAP plasmid decreased the cell invasion and migration. At the molecular level, MTAP knockdown downregulated E-cadherin and p-GSK3β but upregulated Slug expression. Our results indicated that MTAP deletion results in the decreased expression in ESCCs and that it plays a role in promoting the mobility and inducing the epithelial-to-mesenchymal transition of ESCC cells via the GSK3β/Slug/E-cadherin axis. The data suggest that MTAP might function as a tumor suppressor gene in ESCC. Keywords: ESCC, MTAP, deletion, invasion, migration

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