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Tytuł pozycji:

Features of pancreatic lesions on the background gastroduodenal pathology associated with H.pylori-infection

Tytuł:
Features of pancreatic lesions on the background gastroduodenal pathology associated with H.pylori-infection
Autorzy:
T.V. Sorokman
O.-M.V. Popelyuk
O.V. Makarova
N.Ya. Vaskul
Temat:
children
H.pylori-associated gastroduodenal patho-logy
pancreas
Pediatrics
RJ1-570
Źródło:
Zdorovʹe Rebenka, Vol 12, Iss 2, Pp 130-135 (2017)
Wydawca:
Zaslavsky O.Yu., 2017.
Rok publikacji:
2017
Kolekcja:
LCC:Pediatrics
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
Ukrainian
ISSN:
2224-0551
2307-1168
Relacje:
http://childshealth.zaslavsky.com.ua/article/view/99768; https://doaj.org/toc/2224-0551; https://doaj.org/toc/2307-1168
DOI:
10.22141/2224-0551.12.2.2017.99768
Dostęp URL:
https://doaj.org/article/b4b7ecf8e49b46ddbf746fa7a7ce0cc3  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.b4b7ecf8e49b46ddbf746fa7a7ce0cc3
Czasopismo naukowe
Background. There are recent publications about the possible impact of Helicobacter pylori (H.pylori) on the mucous membrane of the stomach or duodenum, as well as the pancreas. This relation is theoretically possible considering the close connection of stomach, duodenum and pancreas. The purpose of the study was the determination of the incidence and characteristics of combined lesions of the pancreas and the upper gastrointestinal tract associated with H.pylori infection in children. Material and methods. A retrospective analysis of medical records of 684 children, who were hospitalized in the gastroenterology department of the Chernivtsi regional children’s hospital during the period from 2010 to 2016. A comprehensive examination included ultrasound diagnostics of the abdomen, esophagogastroduodenoscopy, determination of the activity of serum α-amylase, urine diastase, coprogram assessment. A test system HELIC-test “AMA” (Russia, St. Petersburg) and histological methods (bioptates were taken from the fundal and antral gastric mucosa, after Giemsa stain of histological sections, the visualization of H.pylori was performed by means of light microscopy) were used for the H.pylori diagnosis. The descriptive statistics methods with parametric distribution estimating the mean and standard deviation (M ± SD) were applied. Statistical significance of differences was assessed by Student’s t-test for independent samples. Results. Of the 684 children, who completed a survey, 310 were boys (45.3 %) and 374 — girls (54.7 %) aged 6 to 18 years. The diagnosis of chronic gastroduodenitis was the most frequently registered among examined children (420 out of 684 patients examined, 61.4 %). A rather high number of children had erosive and ulcerative lesions of the stomach and duodenum (157 of 684 patients, 22.9 %). H.pylori infection in a group of the children surveyed was detected in 64.5 % cases. The highest incidence of H.pylori was in children with ulcerative-erosive lesions of the upper gastrointestinal tract — 121 of 157 analyzed, 77.1 %. In more than half of patients (352 of 684 patients, 51.5 %) with gastroduodenal pathology, the pancreas was also involved in the pathological process. In 56.8 % of those with combined lesions, a test for H.pylori was positive. H.pylori was most frequently detected in patients with erosive and ulcerative lesions of the upper gastrointestinal tract and lesions of the pancreas (92 of 119 examined patients, 77.9 %). Patients with H.pylori positive test had 5.1 ± 1.2 points of pain syndrome intensity, whereas those with H.pylori negative test — 2.8 ± 1.0 points (p

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