Efficacy of reduced-fluence photodynamic therapy for serous retinal pigment epithelial detachment with choroidal hyperpermeability

Asako Shibata, Yasuhiro Ohkuma, Takaaki Hayashi, Hiroshi Tsuneoka Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan Background: Very few reports have addressed methods of treatment for idiopathic serous (IS) pigment epithelial detachment (PED). Objective: The purpose of this report was to describe clinical courses of two patients with ISPED in whom reduced-fluence photodynamic therapy (RFPDT) was performed. Case reports: Two patients (a 38-year-old woman and a 42-year-old man) were diagnosed with ISPED. In both patients, indocyanine green angiography revealed an area of choroidal vascular hyperpermeability including hyperfluorescent PED, which was evident at the subfoveal area. Both patients underwent RFPDT at an energy of 25 J/cm2. The PED was seen to have resolved 1 month after the treatment and visual acuity was maintained or improved. There was no posttreatment recurrence of PED after 6 months to 1 year, and no treatment-related adverse events were observed. Conclusion: RFPDT may be an effective and safe method of treatment for ISPED with choroidal vascular hyperpermeability. Keywords: pigment epithelial detachment, central serous chorioretinopathy, reduced-fluence photodynamic therapy