Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Gut bacteria Akkermansia is associated with reduced risk of obesity: evidence from the American Gut Project

Tytuł:
Gut bacteria Akkermansia is associated with reduced risk of obesity: evidence from the American Gut Project
Autorzy:
Qi Zhou
Yanfeng Zhang
Xiaoxia Wang
Ruiyue Yang
Xiaoquan Zhu
Ying Zhang
Chen Chen
Huiping Yuan
Ze Yang
Liang Sun
Temat:
Gut microbiota
16S rRNA
Obesity
Body mass index
Probiotics
Akkermansia
Nutrition. Foods and food supply
TX341-641
Nutritional diseases. Deficiency diseases
RC620-627
Źródło:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-9 (2020)
Wydawca:
BMC, 2020.
Rok publikacji:
2020
Kolekcja:
LCC:Nutrition. Foods and food supply
LCC:Nutritional diseases. Deficiency diseases
Typ dokumentu:
article
Opis pliku:
electronic resource
Język:
English
ISSN:
1743-7075
Relacje:
http://link.springer.com/article/10.1186/s12986-020-00516-1; https://doaj.org/toc/1743-7075
DOI:
10.1186/s12986-020-00516-1
Dostęp URL:
https://doaj.org/article/db8b299f13c14d18b5320269b7b8a014  Link otwiera się w nowym oknie
Numer akcesji:
edsdoj.b8b299f13c14d18b5320269b7b8a014
Czasopismo naukowe
Abstract Background Gut bacteria Akkermansia has been shown an anti-obesity protective effect in previous studies and may be used as promising probiotics. However, the above effect may be confounded by common factors, such as sex, age and diets, which should be verified in a generalized population. Methods We used datasets from the American Gut Project to strictly reassess the association and further examined the effect of aging on it. A total of 10,534 participants aged 20 to 99 years from the United States and the United Kingdom were included. The relative abundance of Akkermansia was assessed based on 16S rRNA sequencing data. Obesity (body mass index, BMI ≥ 30 kg/m2) risks were compared across Akkermansia quintiles in logistic models with adjustment for common confounders. Restricted cubic splines were used to examine dose response effects between Akkermansia, obesity and age. A sliding-windows-based algorithm was used to investigate the effect of aging on Akkermansia-obesity associations. Results The median abundance of Akkermansia was 0.08% (interquartile range: 0.006–0.93%), and the prevalence of obesity was 11.03%. Nonlinear association was detected between Akkermansia and obesity risk (P = 0.01). The odds ratios (95% confidence interval) for obesity across the increasing Akkermansia quintiles (referencing to the first quintile) were 1.14 (0.94–1.39), 0.94 (0.77–1.15), 0.70 (0.56–0.85) and 0.79 (0.64–0.96) after adjusting for age and sex (P for trend
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies