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Tytuł pozycji:

Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer

Tytuł :
Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer
Autorzy :
Silas Antonio Juvencio de Freitas Filho
Cláudia Malheiros Coutinho-Camillo
Katia Klug Oliveira
Bárbara Beltrame Bettim
Clóvis Antônio Lopes Pinto
Luiz Paulo Kowalski
Denise Tostes Oliveira
Pokaż więcej
Temat :
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Źródło :
Journal of Oncology, Vol 2021 (2021)
Wydawca :
Hindawi Limited, 2021.
Rok publikacji :
2021
Kolekcja :
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Typ dokumentu :
article
Opis pliku :
electronic resource
Język :
English
ISSN :
1687-8469
29102863
Relacje :
https://doaj.org/toc/1687-8469
DOI :
10.1155/2021/6663720
Dostęp URL :
https://doaj.org/article/dbfaea32138b45b29102863b964595a4
Numer akcesji :
edsdoj.bfaea32138b45b29102863b964595a4
Czasopismo naukowe
Background. The present study aimed to investigate the clinical significance and prognostic value of the immunoexpression of cancer stem cell markers, ALDH1 and Notch1, in subtypes of oral squamous cell carcinoma. Materials and Methods. The expression of ALDH1 and Notch1 in 63 patients with well and poorly differentiated oral squamous cell carcinomas and their subtypes, verrucous carcinoma and basaloid squamous cell carcinoma, was evaluated by immunohistochemistry. The semi-quantitative analysis of the ALDH1 and Notch immunoexpression levels, based on the capture of 10 microscopic fields, at 400X magnification, at the invasive tumor front was performed and associated with clinicopathological variables using the chi-square test or Fisher’s exact test. The overall and disease-free survival rates were estimated according to the Kaplan–Meier method and the curves were compared using the log-rank test. The independent effects of variables were calculated using Cox’s proportional hazards regression model. Results. Strong ALDH1 and Notch1 expression was observed in 16 (25.4%) and 27 (42.9%) oral squamous cell carcinomas including their subtypes, respectively. Most tumors with strong immunoexpression of ALDH1 were basaloid squamous cell carcinoma (56.3%). Statistically significant associations were observed between the strong immunoexpression of Notch1 in poorly differentiated oral squamous cell carcinoma with perineural infiltration (p = 0.011) and lymph node involvement (pN+) (p = 0.034). The strong immunoexpression of ALDH1 was a prognostic factor associated with worse overall survival (p = 0.040) for patients with oral cancer. Conclusion. The strong immunoexpression of Notch1 can contribute to identification of patients with poorly differentiated oral squamous cell carcinoma, who have perineural infiltration or lymph node metastasis. In addition, the strong immunoexpression of ALDH1 may help to identify a worse prognosis in patients with oral squamous cell carcinoma and their subtypes.

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