Chunke Dong,1,* Hongyu Wei,2,* Yuting Zhu,3 Jun Zhou,2 Haoning Ma2 1Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of China; 2Department of Orthopaedic Surgery, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 3Beijing Tongzhou Integrative Medicine Hospital, Beijing 101100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunke DongBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, No.23, Art Gallery Back Street, Dongcheng District, Beijing 100010, People’s Republic of ChinaEmail 1021235338@qq.comPurpose: The current study aimed to compare the clinical and radiographic results of the 3D-printed artificial vertebral body (3DP-AVB) and titanium mesh cage (TMC) for the treatment of Kümmell’s disease (KD) complicated by neurological deficits.Patients and Methods: From January 2014 to July 2018, 28 consecutive patients diagnosed with KD and nerve injuries in our department were treated by posterior vertebral column resection and internal fixation. The patients were divided into two groups (3DP-AVB group and TMC group) based on the different anterior column reconstruction implants. Clinical and radiographic parameters were used to evaluate the outcomes.Results: The two groups achieved excellent clinical and radiographic results 1 month after surgery with no significant difference (P> 0.05), while 3DP-AVB group showed better outcomes compared with TMC group during the follow-up after 6 months (P< 0.05). The risk of subsidence in 3DP-AVB group was lower than that in TMC group (41.6% vs 87.5%, P< 0.05), and severe subsidence (≥ 5 mm) was correlated with the recurrence of back pain and bad daily life function. No significant difference was found in the improvement of neurological function between the two groups (P> 0.05). The blood loss and operation time in 3DP-AVB group were significantly less than both in TMC group (P< 0.05).Conclusion: The lower incidence of cage subsidence, with a better long-term efficacy in maintaining the height of the fused segment, relieving back pain, and improving daily life function indicates that the 3DP-AVB may be a superior alternative for KD with neurological deficits.Keywords: Kümmell’s disease, 3D printing, artificial vertebral body, spinal reconstruction, vertebral column resection, neurological deficits
