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Title of the item:

Simultaneous EEG-fMRI in Patients with Unverricht-Lundborg Disease: Event-Related Desynchronization/Synchronization and Hemodynamic Response Analysis

Title :
Simultaneous EEG-fMRI in Patients with Unverricht-Lundborg Disease: Event-Related Desynchronization/Synchronization and Hemodynamic Response Analysis
Authors :
Elisa Visani
Ludovico Minati
Laura Canafoglia
Isabella Gilioli
Lucia Salvatoni
Giulia Varotto
Patrik Fazio
Domenico Aquino
Maria Grazia Bruzzone
Silvana Franceschetti
Ferruccio Panzica
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Subject Terms :
Computer applications to medicine. Medical informatics
R858-859.7
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Source :
Computational Intelligence and Neuroscience, Vol 2010 (2010)
Publisher :
Hindawi Limited, 2010.
Publication Year :
2010
Collection :
LCC:Computer applications to medicine. Medical informatics
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
Document Type :
article
File Description :
electronic resource
Language :
English
ISSN :
1687-5265
1687-5273
Relation :
https://doaj.org/toc/1687-5265; https://doaj.org/toc/1687-5273
DOI :
10.1155/2010/164278
Access URL :
https://doaj.org/article/cfa77eb2796b4fffb10f2b98003fbe23
Accession Number :
edsdoj.fa77eb2796b4fffb10f2b98003fbe23
Academic Journal
We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related desynchronization/synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD.

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